Unraveling psychiatric disorders through neural single-cell transcriptomics approaches
SN Chehimi, RC Crist, BC Reiner - Genes, 2023 - mdpi.com
The development of single-cell and single-nucleus transcriptome technologies is enabling
the unraveling of the molecular and cellular heterogeneity of psychiatric disorders. The …
the unraveling of the molecular and cellular heterogeneity of psychiatric disorders. The …
Multi-level variations of lateral habenula in depression: A comprehensive review of current evidence
GM Zhang, HY Wu, WQ Cui, W Peng - Frontiers in psychiatry, 2022 - frontiersin.org
Despite extensive research in recent decades, knowledge of the pathophysiology of
depression in neural circuits remains limited. Recently, the lateral habenula (LHb) has been …
depression in neural circuits remains limited. Recently, the lateral habenula (LHb) has been …
Plasticity of neuronal dynamics in the lateral habenula for cue-punishment associative learning
The brain's ability to associate threats with external stimuli is vital to execute essential
behaviours including avoidance. Disruption of this process contributes instead to the …
behaviours including avoidance. Disruption of this process contributes instead to the …
Fluoxetine treatment supports predictive validity of the three hit model of depression in male PACAP heterozygous mice and underpins the impact of early life adversity …
According to the three hit concept of depression, interaction of genetic predisposition altered
epigenetic programming and environmental stress factors contribute to the disease. Earlier …
epigenetic programming and environmental stress factors contribute to the disease. Earlier …
Female reproductive functions of the neuropeptide PACAP
M Koppan, Z Nagy, I Bosnyak, D Reglodi - Frontiers in Endocrinology, 2022 - frontiersin.org
Pituitary adenylate cyclase activating polypeptide (PACAP) is a neuropeptide originally
isolated as a hypothalamic peptide. It has a widespread distribution in the body and has a …
isolated as a hypothalamic peptide. It has a widespread distribution in the body and has a …
The behavioral relevance of a modular organization in the lateral habenula
Behavioral strategies for survival rely on the updates the brain continuously makes based on
the surrounding environment. External stimuli—neutral, positive, and negative—relay core …
the surrounding environment. External stimuli—neutral, positive, and negative—relay core …
Small-molecule non-peptide antagonists of the PACAP receptor attenuate acute restraint stress-induced anxiety-like behaviors in mice
Y Shintani, A Hayata-Takano, Y Yamano… - Biochemical and …, 2022 - Elsevier
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a highly conserved pleiotropic
neuropeptide, implicated in emotional stress responses and anxiety-related disorders. Here …
neuropeptide, implicated in emotional stress responses and anxiety-related disorders. Here …
[PDF][PDF] A depresszió három találat elméletén alapuló állatmodell prediktív validitásának vizsgálata az epigenom változásainak tükrében
G Tamás - 2023 - pea.lib.pte.hu
A hangulatzavarok előfordulási gyakorisága meredeken emelkedik. Leggyakoribb formája,
a májor depresszió önmagában több mint 280 millió embert érint világszerte a WHO adatai …
a májor depresszió önmagában több mint 280 millió embert érint világszerte a WHO adatai …