Therapeutic effects of thymoquinone in doxorubicin‐induced hepatotoxicity via oxidative stress, inflammation and apoptosis
Cancer is a lethal disease that is characterized by uncontrolled cell division and
proliferation, and it results in death in many organisms. Doxorubicin (DOX) is a therapeutic …
proliferation, and it results in death in many organisms. Doxorubicin (DOX) is a therapeutic …
Thymoquinone has a neuroprotective effect against inflammation, oxidative stress, and endoplasmic reticulum stress in the brain cortex, medulla, and hippocampus …
Although doxorubicin (DOX) is used in many cancer treatments, it causes neurotoxicity. In
this study, the effect of thymoquinone (THQ), a powerful antioxidant, on DOX‐induced …
this study, the effect of thymoquinone (THQ), a powerful antioxidant, on DOX‐induced …
Potential Hepatoprotective Effects of Chamaecyparis lawsoniana against Methotrexate-Induced Liver Injury: Integrated Phytochemical Profiling, Target Network …
Methotrexate (MTX) therapy encounters significant limitations due to the significant concern
of drug-induced liver injury (DILI), which poses a significant challenge to its usage. To …
of drug-induced liver injury (DILI), which poses a significant challenge to its usage. To …
Metabolic modeling of sex-specific liver tissue suggests mechanism of differences in toxicological responses
Male subjects in animal and human studies are disproportionately used for toxicological
testing. This discrepancy is evidenced in clinical medicine where females are more likely …
testing. This discrepancy is evidenced in clinical medicine where females are more likely …
Chloroquine attenuates chronic hypoxia‐induced testicular damage via suppressing endoplasmic reticulum stress and apoptosis in experimental rat model
Chronic hypoxia negatively affects male fertility by causing pathological changes in male
reproductive system. However, underlying mechanisms of this damage are unknown …
reproductive system. However, underlying mechanisms of this damage are unknown …
Thymoquinone regulates nitric oxide synthase enzymes and receptor-interacting serine-threonine kinases in isoproterenol-induced myocardial infarcted rats
N Deger, R Ozmen, D Karabulut - Chemico-Biological Interactions, 2022 - Elsevier
This study aims to investigate the protective effects of thymoquinone (THQ) in isoproterenol
(ISO)-induced myocardial infarction (MI) in rats. Thirty-two rats were divided into four equal …
(ISO)-induced myocardial infarction (MI) in rats. Thirty-two rats were divided into four equal …
The prophylactic effect of vitamin C and vitamin B12 against ultraviolet-C-induced hepatotoxicity in male rats
AA Attia, HA Hamad, MA Fawzy, SR Saleh - Molecules, 2023 - mdpi.com
Ultraviolet C (UVC) devices are an effective means of disinfecting surfaces and protecting
medical tools against various microbes, including coronavirus. Overexposure to UVC can …
medical tools against various microbes, including coronavirus. Overexposure to UVC can …
Nitazoxanide mitigates methotrexate hepatotoxicity in rats: role in inhibiting apoptosis and regulating endoplasmic reticulum stress
NM Mahmoud, SM Elshazly, F El-Shaarawy… - Frontiers in …, 2024 - frontiersin.org
Objectives Hepatotoxicity is a severe outcome of methotrexate (MTX) therapy, limiting its
clinical use and contributing to its related morbidity and mortality. This study investigated the …
clinical use and contributing to its related morbidity and mortality. This study investigated the …
Mangiferin mitigates methotrexate-induced liver injury and suppresses hepatic stellate cells activation in rats: imperative role of Nrf2/NF-κB/NLRP3 signaling axis
Ethnopharmacological relevance Mangifera indica (family Anacardiaceae), often
acknowledged as mango and renowned for being a plant of diverse ethnopharmacological …
acknowledged as mango and renowned for being a plant of diverse ethnopharmacological …
Evaluation by different mechanisms of the protective effects of vitamin B12 on methotrexate nephrotoxicity
Methotrexate is used for cure of many cancer types. It has many side effects. For this reason,
obtaining a nephroprotective agent is obligatory. In the study, our aim is to determine …
obtaining a nephroprotective agent is obligatory. In the study, our aim is to determine …