Plant-based biopharmaceutical engineering
L Eidenberger, B Kogelmann… - Nature Reviews …, 2023 - nature.com
Plants can be engineered to recombinantly produce high-quality proteins such as
therapeutic proteins and vaccines, also known as molecular farming. Molecular farming can …
therapeutic proteins and vaccines, also known as molecular farming. Molecular farming can …
Galectins
RD Cummings, FT Liu, GA Rabinovich, SR Stowell… - 2022 - ri.conicet.gov.ar
Galectins are among the most widely expressed class of lectins in all organisms. They
typically bind β-galactose-containing glycoconjugates and share primary structural …
typically bind β-galactose-containing glycoconjugates and share primary structural …
Structural basis for antibody-mediated neutralization of Lassa virus
KM Hastie, MA Zandonatti, LM Kleinfelter, ML Heinrich… - Science, 2017 - science.org
The arenavirus Lassa causes severe hemorrhagic fever and a significant disease burden in
West Africa every year. The glycoprotein, GPC, is the sole antigen expressed on the viral …
West Africa every year. The glycoprotein, GPC, is the sole antigen expressed on the viral …
Reticulons promote formation of ER-derived double-membrane vesicles that facilitate SARS-CoV-2 replication
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the etiologic agent for the
global COVID-19 pandemic, triggers the formation of endoplasmic reticulum (ER)-derived …
global COVID-19 pandemic, triggers the formation of endoplasmic reticulum (ER)-derived …
Assembly and cellular exit of coronaviruses: Hijacking an unconventional secretory pathway from the pre-Golgi intermediate compartment via the Golgi ribbon to the …
Coronaviruses (CoVs) assemble by budding into the lumen of the intermediate compartment
(IC) at the endoplasmic reticulum (ER)-Golgi interface. However, why CoVs have chosen the …
(IC) at the endoplasmic reticulum (ER)-Golgi interface. However, why CoVs have chosen the …
[HTML][HTML] Role of the early secretory pathway in SARS-CoV-2 infection
D Sicari, A Chatziioannou, T Koutsandreas… - Journal of Cell …, 2020 - rupress.org
Similar to other RNA viruses, SARS-CoV-2 must (1) enter a target/host cell,(2) reprogram it
to ensure its replication,(3) exit the host cell, and (4) repeat this cycle for exponential growth …
to ensure its replication,(3) exit the host cell, and (4) repeat this cycle for exponential growth …
Complex N-linked glycans serve as a determinant for exosome/microvesicle cargo recruitment
Y Liang, WS Eng, DR Colquhoun, RR Dinglasan… - Journal of Biological …, 2014 - ASBMB
Exosomes, also known as microvesicles (EMVs), are nano-sized membranous particles
secreted from nearly all mammalian cell types. These nanoparticles play critical roles in …
secreted from nearly all mammalian cell types. These nanoparticles play critical roles in …
Multifunctional role of exosomes in viral diseases: From transmission to diagnosis and therapy
P Chaudhari, V Ghate, M Nampoothiri, S Lewis - Cellular signalling, 2022 - Elsevier
Efforts to discover antiviral drugs and diagnostic platforms have intensified to an
unprecedented level since the outbreak of COVID-19. Nano-sized endosomal vesicles …
unprecedented level since the outbreak of COVID-19. Nano-sized endosomal vesicles …
Viral journeys on the intracellular highways
M Robinson, S Schor, R Barouch-Bentov… - Cellular and Molecular …, 2018 - Springer
Viruses are obligate intracellular pathogens that are dependent on cellular machineries for
their replication. Recent technological breakthroughs have facilitated reliable identification …
their replication. Recent technological breakthroughs have facilitated reliable identification …
DIA-based proteome profiling of nasopharyngeal swabs from COVID-19 patients
DG Mun, PM Vanderboom… - Journal of Proteome …, 2021 - ACS Publications
Since the recent outbreak of COVID-19, there have been intense efforts to understand viral
pathogenesis and host immune response to combat SARS-CoV-2. It has become evident …
pathogenesis and host immune response to combat SARS-CoV-2. It has become evident …