Two decades-long journey from riluzole to edaravone: revisiting the clinical pharmacokinetics of the only two amyotrophic lateral sclerosis therapeutics
The recent approval of edaravone has provided an intravenous option to treat amyotrophic
lateral sclerosis (ALS) in addition to the existing oral agent, riluzole. The present work was …
lateral sclerosis (ALS) in addition to the existing oral agent, riluzole. The present work was …
Rat plasma protein binding of kaempferol‐3‐O‐rutinoside from Lu'an GuaPian tea and its anti‐inflammatory mechanism for cardiovascular protection
F Hua, P Zhou, P Liu, GH Bao - Journal of Food Biochemistry, 2021 - Wiley Online Library
Previous study found a high content of kaempferol‐3‐O‐rutinoside (KR) in Lu'an GuaPian
tea, however, the rat plasma protein binding and mechanism of KR for cardiovascular …
tea, however, the rat plasma protein binding and mechanism of KR for cardiovascular …
Interaction of citrinin with human serum albumin
Citrinin (CIT) is a mycotoxin produced by several Aspergillus, Penicillium, and Monascus
species. CIT occurs worldwide in different foods and drinks and causes health problems for …
species. CIT occurs worldwide in different foods and drinks and causes health problems for …
Inhibitory Mechanisms of Lekethromycin in Dog Liver Cytochrome P450 Enzymes Based on UPLC-MS/MS Cocktail Method
P Sun, Y Cao, J Qiu, J Kong, S Zhang, X Cao - Molecules, 2023 - mdpi.com
Lekethromycin (LKMS) is a synthetic macrolide compound derivative intended for use as a
veterinary medicine. Since there have been no in vitro studies evaluating its potential for …
veterinary medicine. Since there have been no in vitro studies evaluating its potential for …
Studies of drug interactions with alpha1-acid glycoprotein by using on-line immunoextraction and high-performance affinity chromatography
A method that combined on-line immunoextraction with high-performance affinity
chromatography was developed to examine the binding of drugs with α 1-acid glycoprotein …
chromatography was developed to examine the binding of drugs with α 1-acid glycoprotein …
Plasma Protein Binding Rate and Pharmacokinetics of Lekethromycin in Rats
P Sun, H Xiao, J Qiu, Y Cao, J Kong, S Zhang, X Cao - Antibiotics, 2022 - mdpi.com
Lekethromycin (LKMS), a novel macrolide lactone, is still unclear regarding its absorption.
Thus, we conducted this study to investigate the characteristics of LKMS in rats. We chose …
Thus, we conducted this study to investigate the characteristics of LKMS in rats. We chose …
Study on the plasma protein binding rate and compatibility regularity of the constituents migrating to blood of Simiao Yong'an decoction
X Yu, Q Jiao, Y Jiang, S Guo, W Zhang… - Current Drug …, 2020 - ingentaconnect.com
Objective: To study the compatibility regularity of Simiao Yong'an decoction by determining
the plasma protein binding rate with the constituents in Simiao Yong'an decoction and to …
the plasma protein binding rate with the constituents in Simiao Yong'an decoction and to …
Effect of Ling-Gui-Zhu-Gan decoction major components on the plasma protein binding of metoprolol using UPLC analysis coupled with ultrafiltration
P Zhou, J Huang, W Ding - RSC advances, 2018 - pubs.rsc.org
Using traditional Chinese medicine formula Ling-Gui-Zhu-Gan decoction (LGZGD) plus
selective β1-adrenergic receptor inhibitor metoprolol to treat arrhythmia of coronary heart …
selective β1-adrenergic receptor inhibitor metoprolol to treat arrhythmia of coronary heart …
Confirming therapeutic target of protopine using immobilized β2‐adrenoceptor coupled with site‐directed molecular docking and the target‐drug interaction by …
G Liu, P Wang, C Li, J Wang, Z Sun… - Journal of Molecular …, 2017 - Wiley Online Library
Drug‐protein interaction analysis is pregnant in designing new leads during drug discovery.
We prepared the stationary phase containing immobilized β2‐adrenoceptor (β2‐AR) by …
We prepared the stationary phase containing immobilized β2‐adrenoceptor (β2‐AR) by …
Pharmacokinetic profiles contribute to the differences in behavioral pharmacology of 071031B enantiomers as novel serotonin and norepinephrine reuptake inhibitors
R Xue, Y Li, XH He, ZL Jin, SY Fan… - Journal of …, 2017 - journals.sagepub.com
Our previous study indicated that a chiral compound 071031B was a novel serotonin and
noradrenaline reuptake inhibitor with superior antidepressant activity compared to …
noradrenaline reuptake inhibitor with superior antidepressant activity compared to …