Emerging role of PD-1 in the central nervous system and brain diseases
Programmed cell death protein 1 (PD-1) is an immune checkpoint modulator and a major
target of immunotherapy as anti-PD-1 monoclonal antibodies have demonstrated …
target of immunotherapy as anti-PD-1 monoclonal antibodies have demonstrated …
Endogenous opiates and behavior: 2022
RJ Bodnar - Peptides, 2023 - Elsevier
This paper is the forty-fifth consecutive installment of the annual anthological review of
research concerning the endogenous opioid system, summarizing articles published during …
research concerning the endogenous opioid system, summarizing articles published during …
STING controls nociception via type I interferon signalling in sensory neurons
The innate immune regulator STING is a critical sensor of self-and pathogen-derived DNA.
DNA sensing by STING leads to the induction of type-I interferons (IFN-I) and other …
DNA sensing by STING leads to the induction of type-I interferons (IFN-I) and other …
IL-23/IL-17A/TRPV1 axis produces mechanical pain via macrophage-sensory neuron crosstalk in female mice
Although sex dimorphism is increasingly recognized as an important factor in pain, female-
specific pain signaling is not well studied. Here we report that administration of IL-23 …
specific pain signaling is not well studied. Here we report that administration of IL-23 …
STING suppresses bone cancer pain via immune and neuronal modulation
Patients with advanced stage cancers frequently suffer from severe pain as a result of bone
metastasis and bone destruction, for which there is no efficacious treatment. Here, using …
metastasis and bone destruction, for which there is no efficacious treatment. Here, using …
PD-1 blockade inhibits osteoclast formation and murine bone cancer pain
Emerging immune therapy, such as with the anti–programmed cell death–1 (anti–PD-1)
monoclonal antibody nivolumab, has shown efficacy in tumor suppression. Patients with …
monoclonal antibody nivolumab, has shown efficacy in tumor suppression. Patients with …
PD-L1/PD-1 checkpoint pathway regulates hippocampal neuronal excitability and learning and memory behavior
Summary Programmed death protein 1 (PD-1) and its ligand PD-L1 constitute an immune
checkpoint pathway. We report that neuronal PD-1 signaling regulates learning/memory in …
checkpoint pathway. We report that neuronal PD-1 signaling regulates learning/memory in …
Central opioid receptors mediate morphine-induced itch and chronic itch via disinhibition
Opioids such as morphine are mainstay treatments for clinical pain conditions. Itch is a
common side effect of opioids, particularly as a result of epidural or intrathecal …
common side effect of opioids, particularly as a result of epidural or intrathecal …
Inhibiting Hv1 channel in peripheral sensory neurons attenuates chronic inflammatory pain and opioid side effects
Q Zhang, Y Ren, Y Mo, P Guo, P Liao, Y Luo, J Mu… - Cell Research, 2022 - nature.com
Both opioids and nonsteroidal anti-inflammatory drugs (NSAIDS) produce deleterious side
effects and fail to provide sustained relief in patients with chronic inflammatory pain …
effects and fail to provide sustained relief in patients with chronic inflammatory pain …
A novel spinal neuron connection for heat sensation
Heat perception enables acute avoidance responses to prevent tissue damage and
maintain body thermal homeostasis. Unlike other modalities, how heat signals are …
maintain body thermal homeostasis. Unlike other modalities, how heat signals are …