[HTML][HTML] Drugs in clinical development to treat autosomal dominant polycystic kidney disease
T Bais, RT Gansevoort, E Meijer - Drugs, 2022 - Springer
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive
cyst formation that ultimately leads to kidney failure in most patients. Approximately 10% of …
cyst formation that ultimately leads to kidney failure in most patients. Approximately 10% of …
[HTML][HTML] The biology of vasopressin
S Sparapani, C Millet-Boureima, J Oliver, K Mu… - Biomedicines, 2021 - mdpi.com
Vasopressins are evolutionarily conserved peptide hormones. Mammalian vasopressin
functions systemically as an antidiuretic and regulator of blood and cardiac flow essential for …
functions systemically as an antidiuretic and regulator of blood and cardiac flow essential for …
[HTML][HTML] In silico repurposed drugs against monkeypox virus
Monkeypox is an emerging epidemic of concern. The disease is caused by the monkeypox
virus and an increasing global incidence with a 2022 outbreak that has spread to Europe …
virus and an increasing global incidence with a 2022 outbreak that has spread to Europe …
Modern trends in diuretics development
Diuretics are the first-line therapy for widespread cardiovascular and non-cardiovascular
diseases. Traditional diuretics are commonly prescribed for treatment in patients with …
diseases. Traditional diuretics are commonly prescribed for treatment in patients with …
AQP2 trafficking in health and diseases: an updated overview
Renal collecting duct principal cells play a key role in controlling body water balance.
Principal cells express the water channels AQP2, AQP3, and AQP4 that mediate renal water …
Principal cells express the water channels AQP2, AQP3, and AQP4 that mediate renal water …
Many kinases for controlling the water channel aquaporin‐2
A Kharin, E Klussmann - The Journal of Physiology, 2023 - Wiley Online Library
Abstract Aquaporin‐2 (AQP2) is a member of the aquaporin water channel family. In the
kidney, AQP2 is expressed in collecting duct principal cells where it facilitates water …
kidney, AQP2 is expressed in collecting duct principal cells where it facilitates water …
[HTML][HTML] Pre‐clinical evaluation of dual targeting of the GPCRs CaSR and V2R as therapeutic strategy for autosomal dominant polycystic kidney disease
A Di Mise, X Wang, H Ye, L Pellegrini… - The FASEB …, 2021 - ncbi.nlm.nih.gov
Autosomal dominant polycystic kidney disease (ADPKD), caused by mutations of PKD1 or
PKD2 genes, is characterized by development and growth of cysts causing progressive …
PKD2 genes, is characterized by development and growth of cysts causing progressive …
[HTML][HTML] Hyponatremia
H Rondon, M Badireddy - 2017 - europepmc.org
Hyponatremia - Abstract - Europe PMC Sign in | Create an account https://orcid.org Europe
PMC Menu About Tools Developers Help Contact us Helpdesk Feedback Twitter Blog Tech …
PMC Menu About Tools Developers Help Contact us Helpdesk Feedback Twitter Blog Tech …
[HTML][HTML] Olive Leaf Extract (OLE) impaired vasopressin-induced aquaporin-2 trafficking through the activation of the calcium-sensing receptor
Vasopressin (AVP) increases water permeability in the renal collecting duct through the
regulation of aquaporin-2 (AQP2) trafficking. Several disorders, including hypertension and …
regulation of aquaporin-2 (AQP2) trafficking. Several disorders, including hypertension and …
Renal Ciliopathies: Promising drug targets and prospects for clinical trials
L Devlin, P Dhondurao Sudhindar… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Renal ciliopathies represent a collection of genetic disorders characterized by
deficiencies in the biogenesis, maintenance, or functioning of the ciliary complex. These …
deficiencies in the biogenesis, maintenance, or functioning of the ciliary complex. These …