Alkaline phosphatase: a potential biomarker for stroke and implications for treatment

AL Brichacek, CM Brown - Metabolic brain disease, 2019 - Springer
Stroke is the fifth leading cause of death in the US, with more than 100,000 deaths annually.
There are a multitude of risks associated with stroke, including aging, cardiovascular …

[HTML][HTML] Necrotizing enterocolitis in premature infants—A defect in the brakes? Evidence from clinical and animal studies

V Sampath, M Martinez, M Caplan, MA Underwood… - Mucosal …, 2023 - Elsevier
A key aspect of postnatal intestinal adaptation is the establishment of symbiotic relationships
with co-evolved gut microbiota. Necrotizing enterocolitis (NEC) is the most severe disease …

Alkaline phosphatase: a possible treatment for sepsis-associated acute kidney injury in critically ill patients

E Peters, S Heemskerk, R Masereeuw… - American Journal of …, 2014 - Elsevier
Acute kidney injury (AKI) is a common disease in the intensive care unit and accounts for
high morbidity and mortality. Sepsis, the predominant cause of AKI in this setting, involves a …

The science and necessity of using animal models in the study of necrotizing enterocolitis

GJ Ares, SJ McElroy, CJ Hunter - Seminars in pediatric surgery, 2018 - Elsevier
Necrotizing enterocolitis (NEC) remains one of the highest causes of mortality and of acute
and long-term morbidity in premature infants. Multiple factors are involved in the …

The role of intestinal alkaline phosphatase in the development of necrotizing enterocolitis

RDS Martins, EMW Kooi, K Poelstra… - Early Human …, 2023 - Elsevier
Necrotizing enterocolitis (NEC) is a devastating neonatal disease that affects neonates
worldwide and often leads to high morbidity and mortality rates. Despite extensive research …

The protective effects of fecal microbiota transplantation in an experimental model of necrotizing enterocolitis

C Prado, M Michels, P Ávila, H Burger… - Journal of pediatric …, 2019 - Elsevier
Background Necrotizing enterocolitis (NEC) is a serious disease that affects premature
neonates, causing high mortality. In the search for new options of treatment it was …

Intestinal alkaline phosphatase ameliorates experimental colitis via toll-like receptor 4-dependent pathway

SW Hwang, JH Kim, C Lee, JP Im, JS Kim - European journal of …, 2018 - Elsevier
Intestinal alkaline phosphatase (IAP) is an intestinal brush border enzyme which plays an
important role in gut homeostasis and mucosal inflammation. However, the mechanism of …

S-layer protein 2 of vaginal Lactobacillus crispatus 2029 enhances growth, differentiation, VEGF production and barrier functions in intestinal epithelial cell line Caco …

VM Abramov, IV Kosarev, TV Priputnevich… - International Journal of …, 2021 - Elsevier
We have previously demonstrated the ability of the human vaginal strain Lactobacillus
crispatus 2029 (LC2029) for strong adhesion to cervicovaginal epithelial cells, expression of …

Lipopolysaccharide and soluble CD14 in cord blood plasma are associated with prematurity and chorioamnionitis

DG Martinez-Lopez, NT Funderburg, A Cerissi… - Pediatric …, 2014 - nature.com
Background: Lipopolysaccharide (LPS), an endotoxin of Gram-negative bacteria, causes
preterm birth in animals and has been implicated as a factor triggering preterm labor and …

Intestinal alkaline phosphatase to treat necrotizing enterocolitis

BE Biesterveld, SM Koehler, NP Heinzerling… - Journal of surgical …, 2015 - Elsevier
Background Intestinal alkaline phosphatase (IAP) activity is decreased in necrotizing
enterocolitis (NEC), and IAP supplementation prevents NEC development. It is not known if …