Antibodies and antibody-derived macromolecules have established themselves as the
mainstay in protein-based therapeutic molecules (biologics). Our knowledge of the structure …

Antibodies are the most rapidly growing drug class and have a major impact on human
health, particularly in oncology, autoimmunity and chronic inflammatory diseases. Many of …

Antibody-based proteins have become an important class of biologic therapeutics, due in
large part to the stability, specificity, and adaptability of the antibody framework. Indeed …

BACKGROUND. Intravenous Ig (IVIg), plasma exchange, and immunoadsorption are
frequently used in the management of severe autoimmune diseases mediated by …

The convenience of subcutaneous (SC) administration and the increasing interest in
monoclonal antibody (mAb)-based therapies for chronic diseases, hint their potential for SC …

Recent Ebola virus disease epidemics have highlighted the need for effective vaccines and
therapeutics to prevent future outbreaks. Antibodies are clearly critical for control of this …

The pH-selective interaction between the immunoglobulin G (IgG) fragment crystallizable
region (Fc region) and the neonatal Fc receptor (FcRn) is critical for prolonging the …

Engineering of antibodies for improved pharmacokinetics through enhanced binding to the
neonatal Fc receptor (FcRn) has been demonstrated in transgenic mice, non-human …

The MHC class I-related receptor FcRn serves multiple roles ranging from the regulation of
levels of IgG isotype antibodies and albumin throughout the body to the delivery of antigen …

ABSTRACT A large body of data exists demonstrating that neonatal Fc receptor (FcRn)
binding of an IgG via its Fc CH2-CH3 interface trends with the pharmacokinetics (PK) of IgG …