It is generally accepted that the wide variation in genome size observed among eukaryotic
species is more closely correlated with the amount of repetitive DNA than with the number of …

The evolutionarily conserved Argonaute/PIWI (AGO/PIWI, also known as PAZ-PIWI domain
or PPD) family of proteins is crucial for the biogenesis and function of small noncoding RNAs …

RNA interference (RNAi) is a widespread silencing mechanism that acts at both the
posttranscriptional and transcriptional levels. Here, we describe the purification of an RNAi …

We have developed an inducible system to visualize gene expression at the levels of DNA,
RNA and protein in living cells. The system is composed of a 200 copy transgene array …

The nature of the role played by mobile elements in host genome evolution is reassessed
considering numerous recent developments in many areas of biology. It is argued that easy …

Genes normally resident in euchromatic domains are silenced when packaged into
heterochromatin, as exemplified in Drosophila melanogaster by position effect variegation …

HP1 was first described in Drosophila as a heterochromatin-associated protein with dosage-
dependent effects on heterochromatin-induced gene silencing. Recently, membership of the …

The interface between cellular systems involving small noncoding RNAs and epigenetic
change remains largely unexplored in metazoans. RNA-induced silencing systems have the …

Transposable elements (TEs) are ubiquitous genetic elements, able to jump from one
location of the genome to another, in all organisms. For this reason, on the one hand, TEs …

In plants, recent studies have demonstrated links between the regulation of developmental
processes and chromatin dynamics and organisation. Analysis of new mutations affecting …