HTLV-1 bZIP factor: the key viral gene for pathogenesis

M Matsuoka, JM Mesnard - Retrovirology, 2020 - Springer
Human T cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia-lymphoma (ATL)
and inflammatory diseases. The HTLV-1 bZIP factor (HBZ) gene is constantly expressed in …

Multifaceted functions and roles of HBZ in HTLV-1 pathogenesis

G Ma, J Yasunaga, M Matsuoka - Retrovirology, 2016 - Springer
Human T cell leukemia virus type 1 (HTLV-1) is an oncogenic retrovirus responsible for the
development of adult T-cell leukemia (ATL). Although HTLV-1 harbors an oncogene, tax …

[HTML][HTML] 40 years of the human T-cell leukemia virus: past, present, and future

Y Tagaya, M Matsuoka, R Gallo - F1000Research, 2019 - ncbi.nlm.nih.gov
It has been nearly 40 years since human T-cell leukemia virus-1 (HTLV-1), the first
oncogenic retrovirus in humans and the first demonstrable cause of cancer by an infectious …

Pathogenicity and virulence of human T lymphotropic virus type-1 (HTLV-1) in oncogenesis: adult T-cell leukemia/lymphoma (ATLL)

S Ahmadi Ghezeldasht, DJ Blackbourn… - Critical Reviews in …, 2023 - Taylor & Francis
Adult T-cell leukemia/lymphoma (ATLL) is an aggressive malignancy of CD4+ T
lymphocytes caused by human T lymphotropic virus type-1 (HTLV-1) infection. HTLV-1 was …

Impact of host immunity on HTLV-1 pathogenesis: potential of Tax-targeted immunotherapy against ATL

M Kannagi, A Hasegawa, Y Nagano, S Kimpara… - Retrovirology, 2019 - Springer
Human T-cell leukemia virus type-1 (HTLV-1) causes adult T-cell leukemia/lymphoma (ATL),
HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), and other …

Interplay between innate immunity and the viral oncoproteins Tax and HBZ in the pathogenesis and therapeutic response of HTLV-1 associated adult T cell leukemia

H El Hajj, A Bazarbachi - Frontiers in Immunology, 2022 - frontiersin.org
The Human T-cell Leukemia virus type 1 (HTLV-1) causes an array of pathologies, the most
aggressive of which is adult T-cell leukemia (ATL), a fatal blood malignancy with dismal …

Kinetics of HTLV-1 reactivation from latency quantified by single-molecule RNA FISH and stochastic modelling

M Miura, S Dey, S Ramanayake, A Singh… - PLoS …, 2019 - journals.plos.org
The human T cell leukemia virus HTLV-1 establishes a persistent infection in vivo in which
the viral sense-strand transcription is usually silent at a given time in each cell. However …

The endogenous HBZ interactome in ATL leukemic cells reveals an unprecedented complexity of host interacting partners involved in RNA splicing

M Shallak, T Alberio, M Fasano, M Monti… - Frontiers in …, 2022 - frontiersin.org
Adult T-cell leukemia/lymphoma (ATL) is a T-cell lymphoproliferative neoplasm caused by
the human T-cell leukemia virus type 1 (HTLV-1). Two viral proteins, Tax-1 and HBZ play …

The role of HBZ in HTLV-1-induced oncogenesis

T Zhao - Viruses, 2016 - mdpi.com
Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia (ATL) and
chronic inflammatory diseases. HTLV-1 bZIP factor (HBZ) is transcribed as an antisense …

HTLV-1 HBZ viral protein: a key player in HTLV-1 mediated diseases

M Baratella, G Forlani, RS Accolla - Frontiers in microbiology, 2017 - frontiersin.org
Human T cell leukemia virus type 1 (HTLV-1) is an oncogenic human retrovirus that has
infected 10–15 million people worldwide. After a long latency, 3–5% of infected individuals …