Unnatural helical peptidic foldamers as protein segment mimics

P Sang, J Cai - Chemical Society Reviews, 2023 - pubs.rsc.org
Unnatural helical peptidic foldamers have attracted considerable attention owing to their
unique folding behaviours, diverse artificial protein binding mechanisms, and promising …

Paramyxoviruses: pathogenesis, vaccines, antivirals, and prototypes for pandemic preparedness

WP Duprex, RE Dutch - The Journal of Infectious Diseases, 2023 - academic.oup.com
The Paramyxoviridae family includes established human pathogens such as measles virus,
mumps virus, and the human parainfluenza viruses; highly lethal zoonotic pathogens such …

Murine parainfluenza virus persists in lung innate immune cells sustaining chronic lung pathology

ÍA Castro, Y Yang, V Gnazzo, DH Kim… - Nature …, 2024 - nature.com
Common respiratory viruses, including the human parainfluenza viruses, threaten human
health seasonally and associate with the development of chronic lung diseases. Evidence …

Subnanometer structure of an enveloped virus fusion complex on viral surface reveals new entry mechanisms

TC Marcink, G Zipursky, W Cheng, K Stearns… - Science …, 2023 - science.org
Paramyxoviruses—including important pathogens like parainfluenza, measles, and Nipah
viruses—use a receptor binding protein [hemagglutinin-neuraminidase (HN) for …

A robust mouse model of HPIV-3 infection and efficacy of GS-441524 against virus-induced lung pathology

Y Lin, M Khan, B Weynand, M Laporte… - Nature …, 2024 - nature.com
Human parainfluenza virus type 3 (HPIV-3) can cause severe respiratory tract infections.
There are no convenient small-animal infection models. Here, we show viral replication in …

Comparison of mutations in human parainfluenza viruses during passage in primary human bronchial/tracheal epithelial air-liquid interface cultures and cell lines

S Sugimoto, M Kawase, R Suwa, Y Kume… - Microbiology …, 2024 - journals.asm.org
Human parainfluenza virus (HPIV) causes respiratory infections, which are exacerbated in
children and older people. Correct evaluation of viral characteristics is essential for the study …

Genetic characteristics of human parainfluenza viruses 1–4 associated with acute lower respiratory tract infection in Chinese children, during 2015–2021

Y Zhu, Y Sun, C Li, G Lu, R Jin, B Xu… - Microbiology …, 2024 - journals.asm.org
Human parainfluenza viruses (HPIVs) are a significant cause of acute lower respiratory tract
infections (ALRTIs) among young children and elderly individuals worldwide. The four types …

Functional and structural basis of human parainfluenza virus type 3 neutralization with human monoclonal antibodies

N Suryadevara, AR Otrelo-Cardoso, N Kose… - Nature …, 2024 - nature.com
Human parainfluenza virus type 3 (hPIV3) is a respiratory pathogen that can cause severe
disease in older people and infants. Currently, vaccines against hPIV3 are in clinical trials …

Evidence of recurrent selection of mutations commonly found in SARS-CoV-2 variants of concern in viruses infecting immunocompromised patients

LR Goes, JD Siqueira, MM Garrido, BM Alves… - Frontiers in …, 2022 - frontiersin.org
Chronically immunosuppressed patients infected with SARS-CoV-2 often experience
prolonged virus shedding, and may pave the way to the emergence of mutations that render …

How a paramyxovirus fusion/entry complex adapts to escape a neutralizing antibody

TC Marcink, G Zipursky, EB Sobolik, K Golub… - Nature …, 2024 - nature.com
Paramyxoviruses including measles, Nipah, and parainfluenza viruses are public health
threats with pandemic potential. Human parainfluenza virus type 3 (HPIV3) is a leading …