The incidence of metabolic disorders, as well as of neurodegenerative diseases—mainly the
sporadic forms of Alzheimer's and Parkinson's disease—are increasing worldwide. Notably …

High-density lipoproteins (HDL) play a key role in cholesterol homeostasis maintenance in
the central nervous system (CNS), by carrying newly synthesized cholesterol from astrocytes …

Background: Evidence has revealed an association between familial hypercholesterolemia
and cognitive impairment. In this regard, a connection between cognitive deficits and …

The Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) involvement in Alzheimer's
disease (AD) is poorly investigated. We evaluated the in vitro PCSK9 modulation of …

Familial hypercholesterolemia (FH) is a metabolic condition caused mainly by a mutation in
the low-density lipoprotein (LDL) receptor gene (LDLR), which is highly prevalent in the …

Lipid peroxidation from oxidative stress is considered a major contributor to age-related
macular degeneration (AMD). The retina is abundant with circulating low-density …

Abstract Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized
by a persistent impairment of social skills, including aspects of perception, interpretation …

Perfluorooctane sulfonate (PFOS) is an emerging persistent organic pollutant, and its
potential impact on cognitive function remains unclear. We adopted the C57BL/6J mouse …

Familial hypercholesterolemia (FH) is caused by mutations in the gene that encodes the low‐
density lipoprotein (LDL) receptor, which leads to an excessive increase in plasma LDL …

Background: Ample evidence from clinical and pre-clinical studies suggests mid-life
hypercholesterolemia as a risk factor for developing Alzheimer's disease (AD) at a later age …