Characterizing cis-regulatory elements using single-cell epigenomics
Cell type-specific gene expression patterns and dynamics during development or in disease
are controlled by cis-regulatory elements (CREs), such as promoters and enhancers …
are controlled by cis-regulatory elements (CREs), such as promoters and enhancers …
[HTML][HTML] Single-cell ATAC sequencing analysis: from data preprocessing to hypothesis generation
Most genetic variations associated with human complex traits are located in non-coding
genomic regions. Therefore, understanding the genotype-to-phenotype axis requires a …
genomic regions. Therefore, understanding the genotype-to-phenotype axis requires a …
[HTML][HTML] A single-cell atlas of chromatin accessibility in the human genome
Current catalogs of regulatory sequences in the human genome are still incomplete and lack
cell type resolution. To profile the activity of gene regulatory elements in diverse cell types …
cell type resolution. To profile the activity of gene regulatory elements in diverse cell types …
Single-nucleus RNA and ATAC sequencing reveals the impact of chromatin accessibility on gene expression in Arabidopsis roots at the single-cell level
A Farmer, S Thibivilliers, KH Ryu, J Schiefelbein… - Molecular Plant, 2021 - cell.com
Similar to other complex organisms, plants consist of diverse and specialized cell types. The
gain of unique biological functions of these different cell types is the consequence of the …
gain of unique biological functions of these different cell types is the consequence of the …
Single cell transcriptional and chromatin accessibility profiling redefine cellular heterogeneity in the adult human kidney
The integration of single cell transcriptome and chromatin accessibility datasets enables a
deeper understanding of cell heterogeneity. We performed single nucleus ATAC (snATAC …
deeper understanding of cell heterogeneity. We performed single nucleus ATAC (snATAC …
Single-cell analysis of chromatin accessibility in the adult mouse brain
Recent advances in single-cell technologies have led to the discovery of thousands of brain
cell types; however, our understanding of the gene regulatory programs in these cell types is …
cell types; however, our understanding of the gene regulatory programs in these cell types is …
Genetic and epigenetic coordination of cortical interneuron development
One of the hallmarks of the cerebral cortex is the extreme diversity of interneurons,–. The two
largest subtypes of cortical interneurons, parvalbumin-and somatostatin-positive cells, are …
largest subtypes of cortical interneurons, parvalbumin-and somatostatin-positive cells, are …
[HTML][HTML] Cell-type specialization is encoded by specific chromatin topologies
W Winick-Ng, A Kukalev, I Harabula, L Zea-Redondo… - Nature, 2021 - nature.com
Abstract The three-dimensional (3D) structure of chromatin is intrinsically associated with
gene regulation and cell function,–. Methods based on chromatin conformation capture have …
gene regulation and cell function,–. Methods based on chromatin conformation capture have …
An atlas of gene regulatory elements in adult mouse cerebrum
The mammalian cerebrum performs high-level sensory perception, motor control and
cognitive functions through highly specialized cortical and subcortical structures. Recent …
cognitive functions through highly specialized cortical and subcortical structures. Recent …
A comparative atlas of single-cell chromatin accessibility in the human brain
Recent advances in single-cell transcriptomics have illuminated the diverse neuronal and
glial cell types within the human brain. However, the regulatory programs governing cell …
glial cell types within the human brain. However, the regulatory programs governing cell …