75 years of bovine viral diarrhea virus: Current status and future applications of the use of directed antivirals

BW Newcomer - Antiviral Research, 2021 - Elsevier
Bovine viral diarrhea virus (BVDV) was first reported 75 years ago and remains a source of
major financial and production losses in the North American cattle industry. Currently …

Approved and experimental countermeasures against pestiviral diseases: Bovine viral diarrhea, classical swine fever and border disease

BW Newcomer, MD Givens - Antiviral research, 2013 - Elsevier
The pestiviruses, bovine viral diarrhea virus (BVDV), classical swine fever (CSFV) and
border disease virus, are important livestock pathogens in many countries, but current …

Template entrance channel as possible allosteric inhibition and resistance site for quinolines tricyclic derivatives in RNA dependent RNA polymerase of bovine viral …

M Srivastava, L Mittal, D Sarmadhikari, VK Singh… - Pharmaceuticals, 2023 - mdpi.com
The development of potent non-nucleoside inhibitors (NNIs) could be an alternate strategy
to combating infectious bovine viral diarrhea virus (BVDV), other than the traditional …

Biflavonoids of Dacrydium balansae with potent inhibitory activity on dengue 2 NS5 polymerase

P Coulerie, C Eydoux, E Hnawia, L Stuhl… - Planta …, 2012 - thieme-connect.com
In order to find new molecules for antiviral drug design, we screened 102 ethyl acetate
extracts from New-Caledonian flora for antiviral activity against the dengue 2 virus RNA …

3-Biphenylimidazo [1, 2-a] pyridines or [1, 2-b] pyridazines and analogues, novel Flaviviridae inhibitors

C Enguehard-Gueiffier, S Musiu, N Henry… - European Journal of …, 2013 - Elsevier
Using Ttou 84 as starting point, a novel class of biphenyl derivatives of imidazo [1, 2-a]
pyridine and imidazo [1, 2-b] pyridazine was designed to optimize the inhibitory properties …

Molecular mechanism of viral resistance to a potent non-nucleoside inhibitor unveiled by molecular simulations

S Asthana, S Shukla, P Ruggerone, AV Vargiu - Biochemistry, 2014 - ACS Publications
Recently, we reported on a potent benzimidazole derivative (227G) that inhibits the growth
of the bovine viral diarrhea virus (BVDV) in cell-based and enzyme assays at nanomolar …

Inhibition of bovine viral diarrhea virus RNA synthesis by thiosemicarbazone derived from 5, 6-dimethoxy-1-indanone

EF Castro, LE Fabian, ME Caputto, D Gagey… - Journal of …, 2011 - Am Soc Microbiol
In the present work, we described the activity of the thiosemicarbazone derived from 5, 6-
dimethoxy-1-indanone (TSC), which we previously characterized as a new compound that …

Computational study exploring the interaction mechanism of benzimidazole derivatives as potent cattle bovine viral diarrhea virus inhibitors

J Wang, Y Yang, Y Li, Y Wang - Journal of agricultural and food …, 2016 - ACS Publications
Bovine viral diarrhea virus (BVDV) infections are prevailing in cattle populations on a
worldwide scale. The BVDV RNA-dependent RNA polymerase (RdRp), as a promising …

Yet another ten stories on antiviral drug discovery (part D): paradigms, paradoxes, and paraductions

E De Clercq - Medicinal Research Reviews, 2010 - Wiley Online Library
This review article presents the fourth part (part D) in the series of stories on antiviral drug
discovery. The stories told in part D focus on:(i) the cyclotriazadisulfonamide compounds;(ii) …

Design and optimization of quinazoline derivatives: New non-nucleoside inhibitors of bovine viral diarrhea virus

GA Fernández, EF Castro, RA Rosas… - Frontiers in …, 2020 - frontiersin.org
Bovine viral diarrhea virus (BVDV) belongs to the Pestivirus genus (Flaviviridae). In spite of
the availability of vaccines, the virus is still causing substantial financial losses to the …