[HTML][HTML] Integrated metabolomics and network pharmacology to reveal the mechanisms of hydroxysafflor yellow A against acute traumatic brain injury

T Li, W Zhang, E Hu, Z Sun, P Li, Z Yu, X Zhu… - Computational and …, 2021 - Elsevier
Traumatic brain injury (TBI) has become a leading cause of mortality, morbidity and disability
worldwide. Hydroxysafflor yellow A (HSYA) is effective in treating TBI, but the potential …

The emerging roles of next-generation metabolomics in critical care nutrition

K Li, HHY Tong, Y Chen, Y Sun… - Critical Reviews in Food …, 2024 - Taylor & Francis
Critical illness leads to millions of deaths worldwide each year, with a significant surge due
to the COVID-19 pandemic. Patients with critical illness are frequently associated with …

Chemical profiling of marine seaweed Halimeda gracilis using UPLC-ESI-Q-TOF-MSE and evaluation of anticancer activity targeting PI3K/AKT and intrinsic apoptosis …

V Ramalingam, NN Kumar, M Harshavardhan… - Food Research …, 2022 - Elsevier
Marine seaweeds are predominant for nutraceuticals and have been food source since
ancient times and are currently being used in Chinese medicines and Japanese traditional …

Metabonomics study on orthotopic transplantion mice model of colon cancer treated with Astragalus membranaceus-Curcuma wenyujin in different proportions via …

R Sun, J Gu, X Chang, F Liu, Y Liang, X Yang… - … of Pharmaceutical and …, 2021 - Elsevier
Metabolomics, an important part of systems biology, can reveal the complex pathogenesis of
many diseases and mechanism of Chinese materia medica (CMM). Astragalus …

Integrated metabolomics, network pharmacology and biological verification to reveal the mechanisms of Nauclea officinalis treatment of LPS-induced acute lung …

H Xu, S Xu, L Li, Y Wu, S Mai, Y Xie, Y Tan, A Li… - Chinese Medicine, 2022 - Springer
Background Acute lung injury (ALI) is a severe inflammatory disease, underscoring the
urgent need for novel treatments. Nauclea officinalis Pierre ex Pitard (Danmu in Chinese …

Mahuang decoction antagonizes acute liver failure via modulating tricarboxylic acid cycle and amino acids metabolism

W Liao, Q Jin, J Liu, Y Ruan, X Li, Y Shen… - Frontiers in …, 2021 - frontiersin.org
Acute liver failure (ALF) is a serious clinical disorder with high fatality rates. Mahuang
decoction (MHD), a well-known traditional Chinese medicine, has multiple pharmacological …

UPLC-TOF-MS/MS metabolomics analysis of zebrafish metabolism by spirotetramat

J Zhang, L Qian, C Wang, M Teng, M Duan… - Environmental …, 2020 - Elsevier
Spirotetramat, a member of tetronic and tetramic acid derivatives, is a unique insecticide and
acaricide. Although the effect on zebrafish embryos lipid biosynthesis of spirotetramat has …

Spatial amine metabolomics and histopathology reveal localized brain alterations in subacute traumatic brain injury and the underlying mechanism of herbal treatment

E Hu, T Tang, Y Li, T Li, L Zhu, R Ding… - CNS Neuroscience …, 2024 - Wiley Online Library
Introduction Spatial changes of amine metabolites and histopathology of the whole brain
help to reveal the mechanism of traumatic brain injury (TBI) and treatment. Methods A newly …

[HTML][HTML] Identification of prototype compounds and their metabolites in rats' serum from Xuefu Zhuyu Decoction by UPLC-Q-TOF/MS

X Zhang, Z Jiang, L Zhang, C Xue, X Feng… - Chinese Herbal …, 2023 - Elsevier
Objective As a classic prescription in traditional Chinese medicine, Xuefu Zhuyu Decoction
(XFZYD) has been widely used in the clinical treatment of cardiovascular and …

Combined metabolomics and network pharmacology to elucidate the mechanisms of Dracorhodin Perchlorate in treating diabetic foot ulcer rats

P Deng, H Liang, S Wang, R Hao, J Han… - Frontiers in …, 2022 - frontiersin.org
Background: Diabetic foot ulcer (DFU) is a severe chronic complication of diabetes, that can
result in disability or death. Dracorhodin Perchlorate (DP) is effective for treating DFU, but …