Membrane curvature and its generation by BAR proteins
Membranes are flexible barriers that surround the cell and its compartments. To execute vital
functions such as locomotion or receptor turnover, cells need to control the shapes of their …
functions such as locomotion or receptor turnover, cells need to control the shapes of their …
Cardiac T-tubule microanatomy and function
Unique to striated muscle cells, transverse tubules (t-tubules) are membrane organelles that
consist of sarcolemma penetrating into the myocyte interior, forming a highly branched and …
consist of sarcolemma penetrating into the myocyte interior, forming a highly branched and …
Cardiac BIN1 folds T-tubule membrane, controlling ion flux and limiting arrhythmia
Cardiomyocyte T tubules are important for regulating ion flux. Bridging integrator 1 (BIN1) is
a T-tubule protein associated with calcium channel trafficking that is downregulated in failing …
a T-tubule protein associated with calcium channel trafficking that is downregulated in failing …
The physiology and pathophysiology of T-tubules in the heart
In cardiomyocytes, invaginations of the sarcolemmal membrane called t-tubules are critically
important for triggering contraction by excitation-contraction (EC) coupling. These structures …
important for triggering contraction by excitation-contraction (EC) coupling. These structures …
Bridging integrator 1 (BIN1): form, function, and Alzheimer's disease
MS Tan, JT Yu, L Tan - Trends in molecular medicine, 2013 - cell.com
The bridging integrator 1 (BIN1) gene, also known as amphiphysin 2, has recently been
identified as the most important risk locus for late onset Alzheimer's disease (LOAD), after …
identified as the most important risk locus for late onset Alzheimer's disease (LOAD), after …
[HTML][HTML] Intracellular trafficking pathways of Cx43 gap junction channels
I Epifantseva, RM Shaw - Biochimica et Biophysica Acta (BBA) …, 2018 - Elsevier
Gap Junction (GJ) channels, including the most common Connexin 43 (Cx43), have
fundamental roles in excitable tissues by facilitating rapid transmission of action potentials …
fundamental roles in excitable tissues by facilitating rapid transmission of action potentials …
Interaction of the Joining Region in Junctophilin-2 With the L-Type Ca2+ Channel Is Pivotal for Cardiac Dyad Assembly and Intracellular Ca2+ Dynamics
Rationale: Ca2+-induced Ca2+ release (CICR) in normal hearts requires close
approximation of L-type calcium channels (LTCCs) within the transverse tubules (T-tubules) …
approximation of L-type calcium channels (LTCCs) within the transverse tubules (T-tubules) …
Amphiphysin 2 (BIN1) in physiology and diseases
I Prokic, BS Cowling, J Laporte - Journal of molecular medicine, 2014 - Springer
Amphiphysin 2, also named bridging integrator-1 (BIN1) or SH3P9, has been recently
implicated in rare and common diseases affecting different tissues and physiological …
implicated in rare and common diseases affecting different tissues and physiological …
L-type calcium channel targeting and local signalling in cardiac myocytes
RM Shaw, HM Colecraft - Cardiovascular research, 2013 - academic.oup.com
In the heart, Ca2+ influx via CaV1. 2 L-type calcium channels (LTCCs) is a multi-functional
signal that triggers muscle contraction, controls action potential duration, and regulates gene …
signal that triggers muscle contraction, controls action potential duration, and regulates gene …
Endoplasmic Reticulum–Plasma Membrane Junctions as Sites of Depolarization-Induced Ca2+ Signaling in Excitable Cells
RE Dixon, JS Trimmer - Annual review of physiology, 2023 - annualreviews.org
Membrane contact sites between endoplasmic reticulum (ER) and plasma membrane (PM),
or ER-PM junctions, are found in all eukaryotic cells. In excitable cells they play unique roles …
or ER-PM junctions, are found in all eukaryotic cells. In excitable cells they play unique roles …