Testosterone is the main male sex hormone and is essential for the maintenance of male
secondary sexual characteristics and fertility. Androgen deficiency in young men owing to …

Sex and gender differences are of fundamental importance in most diseases, including
chronic kidney disease (CKD). Men and women with CKD differ with regard to the …

Globally, cardiovascular disease will continue causing most human deaths for the
foreseeable future. The consistent gender gap in life span of approximately 5.6 yr in all …

Chronic kidney disease (CKD) is a common disease worldwide and is associated with high
rates of morbidity and mortality. This review discusses several aspects of the relationship …

Cardiovascular disease (CVD) is a human health crisis that remains the leading cause of
death worldwide. The cytochrome P450 (CYP) class of enzymes are key metabolizers of …

Cancer patients may develop a variety of kidney lesions that impair not only their immediate
survival but also limit the adequate treatment of the underlying malignant process. This …

Sex differences (biological distinctions between males and females) present a complex
interplay of genetic, developmental, biological, and environmental factors. More and more …

Importance The use of androgen deprivation therapy (ADT) in the treatment of advanced
prostate cancer has been shown to delay the clinical progression of the disease. However …

The marked sexual dimorphism that exists in human cardiovascular diseases has led to the
dogmatic concept that testosterone (Tes) has deleterious effects and exacerbates the …

Hormonal derangements at the level of the hypothalamic–pituitary axis are often seen with
the worsening of kidney function. This may not be surprising given the role of the kidney in …