Beyond conventional immune-checkpoint inhibition—novel immunotherapies for renal cell carcinoma
The management of advanced-stage renal cell carcinoma (RCC) has been transformed by
the development of immune-checkpoint inhibitors (ICIs). Nonetheless, most patients do not …
the development of immune-checkpoint inhibitors (ICIs). Nonetheless, most patients do not …
Tumor microenvironment dynamics in clear-cell renal cell carcinoma
Renal cell carcinoma stands out as one of the most immune-infiltrated tumors in pan-cancer
comparisons. Features of the tumor microenvironment heavily affect disease biology and …
comparisons. Features of the tumor microenvironment heavily affect disease biology and …
Reimagining IDO pathway inhibition in cancer immunotherapy via downstream focus on the tryptophan–kynurenine–aryl hydrocarbon axis
Significant progress has been made in cancer immunotherapy with checkpoint inhibitors
targeting programmed cell death protein 1 (PD-1)–programmed death-ligand 1 signaling …
targeting programmed cell death protein 1 (PD-1)–programmed death-ligand 1 signaling …
Inhibiting IDO pathways to treat cancer: lessons from the ECHO-301 trial and beyond
AJ Muller, MG Manfredi, Y Zakharia… - Seminars in …, 2019 - Springer
With immunotherapy enjoying a rapid resurgence based on the achievement of durable
remissions in some patients with agents that derepress immune function, commonly referred …
remissions in some patients with agents that derepress immune function, commonly referred …
Applications of metabolomics to study cancer metabolism
AK Kaushik, RJ DeBerardinis - … et Biophysica Acta (BBA)-Reviews on …, 2018 - Elsevier
Reprogrammed metabolism supports tumor growth and provides a potential source of
therapeutic targets and disease biomarkers. Mass spectrometry-based metabolomics has …
therapeutic targets and disease biomarkers. Mass spectrometry-based metabolomics has …
[HTML][HTML] CD39–A bright target for cancer immunotherapy
S Guo, F Han, W Zhu - Biomedicine & Pharmacotherapy, 2022 - Elsevier
The ATP-adenosine pathway functions as a key modulator of innate and adaptive immunity
within the tumor microenvironment, and cancer immune evasion largely involves the …
within the tumor microenvironment, and cancer immune evasion largely involves the …
Circulating immune bioenergetic, metabolic, and genetic signatures predict melanoma patients' response to anti–pd-1 immune checkpoint blockade
PL Triozzi, ER Stirling, Q Song, B Westwood… - Clinical Cancer …, 2022 - AACR
Purpose: Immunotherapy with checkpoint inhibitors is improving the outcomes of several
cancers. However, only a subset of patients respond. Therefore, predictive biomarkers are …
cancers. However, only a subset of patients respond. Therefore, predictive biomarkers are …
Safety and antitumor activity of α-PD-L1 antibody as monotherapy or in combination with α-TIM-3 antibody in patients with microsatellite instability–high/mismatch …
A Hollebecque, HC Chung, MJ De Miguel… - Clinical Cancer …, 2021 - AACR
Purpose: Immune checkpoint inhibitors show high response rates and durable clinical
benefit in microsatellite instability–high/mismatch repair–deficient (MSI-H/dMMR) tumors …
benefit in microsatellite instability–high/mismatch repair–deficient (MSI-H/dMMR) tumors …
Emerging applications of metabolomics in clinical pharmacology
Metabolic disturbances have been associated with many human diseases, including cancer,
diabetes, and cardiovascular disease. Metabolomics, a rapidly growing member of the …
diabetes, and cardiovascular disease. Metabolomics, a rapidly growing member of the …