New insights into autophagosome–lysosome fusion
S Nakamura, T Yoshimori - Journal of cell science, 2017 - journals.biologists.com
Macroautophagy (autophagy) is a highly conserved intracellular degradation system that is
essential for homeostasis in eukaryotic cells. Due to the wide variety of the cytoplasmic …
essential for homeostasis in eukaryotic cells. Due to the wide variety of the cytoplasmic …
Autophagy pathway: Cellular and molecular mechanisms
L Yu, Y Chen, SA Tooze - Autophagy, 2018 - Taylor & Francis
Macroautophagy/autophagy is an essential, conserved self-eating process that cells perform
to allow degradation of intracellular components, including soluble proteins, aggregated …
to allow degradation of intracellular components, including soluble proteins, aggregated …
Lysosomal size matters
Lysosomes are key cellular catabolic centers that also perform fundamental metabolic,
signaling and quality control functions. Lysosomes are not static and they respond …
signaling and quality control functions. Lysosomes are not static and they respond …
Autophagosome biogenesis and human health
T Kawabata, T Yoshimori - Cell discovery, 2020 - nature.com
Autophagy degrades the cytoplasmic contents engulfed by autophagosomes. Besides
providing energy and building blocks during starvation via random degradation, autophagy …
providing energy and building blocks during starvation via random degradation, autophagy …
The STX17-SNAP47-VAMP7/VAMP8 complex is the default SNARE complex mediating autophagosome–lysosome fusion
F Jian, S Wang, R Tian, Y Wang, C Li, Y Li, S Wang… - Cell Research, 2024 - nature.com
Autophagosome–lysosome fusion mediated by SNARE complexes is an essential step in
autophagy. Two SNAP29-containing SNARE complexes have been extensively studied in …
autophagy. Two SNAP29-containing SNARE complexes have been extensively studied in …
A plant virus hijacks phosphatidylinositol-3, 5-bisphosphate to escape autophagic degradation in its insect vector
H Wang, J Zhang, H Liu, M Wang, Y Dong, Y Zhou… - Autophagy, 2023 - Taylor & Francis
Hosts can initiate macroautophagy/autophagy as an antiviral defense response, while
viruses have developed multiple ways to evade the host autophagic degradation. However …
viruses have developed multiple ways to evade the host autophagic degradation. However …
Targeted disruption of GAK stagnates autophagic flux by disturbing lysosomal dynamics
M Miyazaki, M Hiramoto, N Takano… - International …, 2021 - spandidos-publications.com
The autophagy‑lysosome system allows cells to adapt to environmental changes by
regulating the degradation and recycling of cellular components, and to maintain …
regulating the degradation and recycling of cellular components, and to maintain …
Iron Dysregulation in Parkinson's Disease: Focused on the Autophagy–Lysosome Pathway
LL Chen, YJ Huang, J Cui, N Song… - ACS Chemical …, 2018 - ACS Publications
Parkinson's disease (PD) is the second most common neurodegenerative disease and is
characterized by dopaminergic neuron loss in the substantia nigra pars compacta (SNpc) …
characterized by dopaminergic neuron loss in the substantia nigra pars compacta (SNpc) …
DNA damage-induced autophagy is regulated by inositol polyphosphate synthetases in Candida albicans
J Du, Y Dong, H Zhu, Y Deng, C Sa, Q Yu… - Biochimica et Biophysica …, 2024 - Elsevier
DNA damage-induced autophagy is a new type of autophagy that differs from traditional
macroautophagy; however, this type of autophagy has not been identified in the pathogenic …
macroautophagy; however, this type of autophagy has not been identified in the pathogenic …
Defective ciliogenesis in INPP5E‐related Joubert syndrome
I Hardee, A Soldatos, M Davids… - American Journal of …, 2017 - Wiley Online Library
Joubert syndrome is a neurodevelopmental disorder, characterized by malformation of the
mid and hindbrain leading to the pathognomonic molar tooth appearance of the brainstem …
mid and hindbrain leading to the pathognomonic molar tooth appearance of the brainstem …