Macroautophagy (autophagy) is a highly conserved intracellular degradation system that is
essential for homeostasis in eukaryotic cells. Due to the wide variety of the cytoplasmic …

Macroautophagy/autophagy is an essential, conserved self-eating process that cells perform
to allow degradation of intracellular components, including soluble proteins, aggregated …

Lysosomes are key cellular catabolic centers that also perform fundamental metabolic,
signaling and quality control functions. Lysosomes are not static and they respond …

Autophagy degrades the cytoplasmic contents engulfed by autophagosomes. Besides
providing energy and building blocks during starvation via random degradation, autophagy …

Autophagosome–lysosome fusion mediated by SNARE complexes is an essential step in
autophagy. Two SNAP29-containing SNARE complexes have been extensively studied in …

Hosts can initiate macroautophagy/autophagy as an antiviral defense response, while
viruses have developed multiple ways to evade the host autophagic degradation. However …

The autophagy‑lysosome system allows cells to adapt to environmental changes by
regulating the degradation and recycling of cellular components, and to maintain …

Parkinson's disease (PD) is the second most common neurodegenerative disease and is
characterized by dopaminergic neuron loss in the substantia nigra pars compacta (SNpc) …

DNA damage-induced autophagy is a new type of autophagy that differs from traditional
macroautophagy; however, this type of autophagy has not been identified in the pathogenic …

Joubert syndrome is a neurodevelopmental disorder, characterized by malformation of the
mid and hindbrain leading to the pathognomonic molar tooth appearance of the brainstem …