Progress in the Chemistry of Tetrahydroquinolines

I Muthukrishnan, V Sridharan, JC Menendez - Chemical reviews, 2019 - ACS Publications
Tetrahydroquinoline is one of the most important simple nitrogen heterocycles, being
widespread in nature and present in a broad variety of pharmacologically active …

Recent advances of the Povarov reaction in medicinal chemistry

O Ghashghaei, C Masdeu, C Alonso, F Palacios… - Drug Discovery Today …, 2018 - Elsevier
The Povarov multicomponent reaction consists on the condensation of an aniline, an
aldehyde, and an activated olefin to generate a tetrahydroquinoline adduct with 3 diversity …

Sequential Photoredox Catalysis for Cascade Aerobic Decarboxylative Povarov and Oxidative Dehydrogenation Reactions of N‐Aryl α‐Amino Acids

T Shao, Y Yin, R Lee, X Zhao, G Chai… - Advanced Synthesis & …, 2018 - Wiley Online Library
A visible‐light‐driven sequential photoredox catalysis to allow N‐aryl α‐amino acids to
experience efficient cascade aerobic decarboxylative Povarov and oxidative …

The Chemistry of Aldehydes and Ketones in the Synthesis of Heterocycles-Historical Reactions with a New and Green Perspective

F Martins da Silva, JJ Junior… - Current Organic …, 2024 - benthamdirect.com
The reactivity of aldehydes and ketones carries great potential for multicomponent
heterocyclizations. These reactions are convergent and highly versatile in the development …

The Povarov reaction: a versatile method to synthesize tetrahydroquinolines, quinolines and julolidines

WF de Paiva, Y de Freitas Rego, Â de Fátima… - …, 2022 - thieme-connect.com
The multicomponent Povarov reaction represents a powerful approach for the construction
of substances containing N-heterocyclic frameworks. By using the Povarov reaction, in …

Calix[n]arene-Catalyzed Three-Component Povarov Reaction: Microwave-Assisted Synthesis of Julolidines and Mechanistic Insights

PAS Abranches, WF de Paiva… - The Journal of …, 2018 - ACS Publications
A new one-pot cascade reaction-based application of Povarov reactions with ap-sulfonic
acid calix [4] arene catalyst for the synthesis of a series of 34 julolidine derivatives with …

One-pot diastereoselective synthesis of tetrahydroquinolines from star anise oil in a choline chloride/zinc chloride eutectic mixture

A Peñaranda Gómez… - ACS Sustainable …, 2019 - ACS Publications
In this contribution, a sustainable one-pot diastereoselective synthesis of
tetrahydroquinolines through the aza Diels–Alder reaction is reported starting from star …

Microwave-assisted multicomponent synthesis of julolidines using silica-supported calix [4] arene as heterogeneous catalyst

WF de Paiva, IB Braga, JV de Assis, SMB Castañeda… - Tetrahedron, 2019 - Elsevier
The application of immobilizing calixarene onto the surface of silica using a sol-gel method,
as an efficient heterogeneous catalyst (CX4SO 3 HSi (n)) for multicomponent Povarov …

Facile Synthesis of Benzimidazoles via Oxidative Cyclization of Acyclic Monoterpene Aldehyde with Diamines: Studies on Antimicrobial and in Vivo Evaluation of …

M Vaithiyalingam, R Mohan Kumar… - Chemistry & …, 2023 - Wiley Online Library
Abstract Citral (1a), a bioactive component of Cymbopogon citratus (lemongrass) could be
isolated and semi‐synthetic analogs synthesized with improved therapeutic properties …

Anise essential oil as a sustainable substrate in the multicomponent double Povarov reaction for julolidine synthesis

IB Braga, SMB Castañeda, J Vitor de Assis… - The Journal of …, 2020 - ACS Publications
The use of star anise oil from a natural source as a dienophile in the multicomponent double
Povarov reaction (MCPRs) to produce highly substituted julolidines with diverse …