Trypanothione reductase and superoxide dismutase as current drug targets for Trypanosoma cruzi: an overview of compounds with activity against Chagas disease

I Beltran-Hortelano, S Perez-Silanes… - Current Medicinal …, 2017 - ingentaconnect.com
It has been over a century since Carlos Chagas discovered the Trypanosoma cruzi (T. cruzi)
as the causative agent of Chagas disease (CD), a neglected tropical disease with several …

[HTML][HTML] Acid catalyzed one-pot approach towards the synthesis of curcuminoid systems: unsymmetrical diarylidene cycloalkanones, exploration of their single crystals …

A Ali, ZU Din, M Ibrahim, M Ashfaq, S Muhammad… - RSC …, 2023 - pubs.rsc.org
In the present study crystalline unsymmetrical diarylidene ketone derivatives BNTP and
BDBC have been prepared by two sequential acid catalyzed aldol condensation reactions in …

Synthesis, structural, and intriguing electronic properties of symmetrical bis-aryl-α, β-unsaturated ketone derivatives

A Ali, M Ashfaq, ZU Din, M Ibrahim, M Khalid… - ACS …, 2022 - ACS Publications
Three symmetrical bis-aryl-α, β-unsaturated ketone derivatives, 2, 6-di ((E)-benzylidene)-
cyclohexan-1-one (DBC), 2, 6-bis ((E)-4-chlorobenzylidene) cyclohexan-1-one (BCC), and …

Facile preparation, characterization, SC-XRD and DFT/DTDFT study of diversely functionalized unsymmetrical bis-aryl-α, β-unsaturated ketone derivatives

M Khalid, A Ali, M Adeel, ZU Din, MN Tahir… - Journal of Molecular …, 2020 - Elsevier
The current research work is about the synthesis of diversely functionalized unsymmetrical
mono-carbonyl curcuminoids:(1E, 4E)-1-(2-methoxy-4-nitrophenyl)-5-(4-methoxyphenyl)-2 …

[HTML][HTML] Structure-activity relationship of dibenzylideneacetone analogs against the neglected disease pathogen, Trypanosoma brucei

KR Francisco, L Monti, W Yang, H Park, LJ Liu… - Bioorganic & medicinal …, 2023 - Elsevier
Trypanosoma brucei is a protozoan parasite that causes Human African Trypanosomiasis
(HAT), a neglected tropical disease (NTD) that is endemic in 36 countries in sub-Saharan …

Exploration of structural, electronic and third order nonlinear optical properties of crystalline chalcone systems: Monoarylidene and unsymmetrical diarylidene …

A Ali, M Khalid, ZU Din, HM Asif, M Imran… - Journal of Molecular …, 2021 - Elsevier
In the current study monoarylidene and unsymmetrical diarylidene cycloalkanes, MBMHP,
MABP, MBHP, and MBCP have been prepared. Their molecular structures were confirmed …

[HTML][HTML] Dibenzylideneacetone induces apoptosis in cervical cancer cells through Ros-mediated mitochondrial damage

AP Zani, CP Zani, ZU Din, E Rodrigues-Filho… - Antioxidants, 2023 - mdpi.com
Cervical cancer is a health problem among women worldwide. Considering the limitations of
prevention and antineoplastic chemotherapy against cervical cancer, research is needed to …

Diarylpentanoids, the privileged scaffolds in antimalarial and anti‐infectives drug discovery: A review

AH Ramli, SM Mohd Faudzi - Archiv der Pharmazie, 2023 - Wiley Online Library
Asia is a hotspot for infectious diseases, including malaria, dengue fever, tuberculosis, and
the pandemic COVID‐19. Emerging infectious diseases have taken a heavy toll on public …

Dibenzylideneacetones are potent trypanocidal compounds that affect the Trypanosoma cruzi redox system

D Lazarin-Bidóia, VC Desoti, SC Martins… - Antimicrobial Agents …, 2016 - Am Soc Microbiol
Despite ongoing efforts, the available treatments for Chagas' disease are still unsatisfactory,
especially in the chronic phase of the disease. Our previous study reported the strong …

[HTML][HTML] Molecular design of curcumin analogues with potent antioxidant properties and thermodynamic evaluation of their mechanism of free radical scavenge

IO Alisi, A Uzairu, SE Abechi - Bulletin of the National Research Centre, 2020 - Springer
Background Free radical attack of cellular structures in the human system is the major cause
of various forms of degenerative diseases. Consequently, recent research has been focused …