Interlinked and fundamental aging processes appear to be a root-cause contributor to many
disorders and diseases. One such process is cellular senescence, which entails a state of …

Aging is characterized by systemic chronic inflammation, which is accompanied by cellular
senescence, immunosenescence, organ dysfunction, and age-related diseases. Given the …

Ageing of the immune system, or immunosenescence, contributes to the morbidity and
mortality of the elderly,. To define the contribution of immune system ageing to organism …

Senolytics are a class of drugs that selectively clear senescent cells (SC). The first senolytic
drugs Dasatinib, Quercetin, Fisetin and Navitoclax were discovered using a hypothesis …

Immunosenescence is a process of immune dysfunction that occurs with age and includes
remodeling of lymphoid organs, leading to changes in the immune function of the elderly …

For several decades, understanding ageing and the processes that limit lifespan have
challenged biologists. Thirty years ago, the biology of ageing gained unprecedented …

The global population of individuals over the age of 65 is growing at an unprecedented rate
and is expected to reach 1.6 billion by 2050. Most older individuals are affected by multiple …

With the ageing of the global population, interest is growing in the 'geroscience hypothesis',
which posits that manipulation of fundamental ageing mechanisms will delay (in parallel) the …

Summary Background Randomised controlled trials (RCTs) inform prescription guidelines,
but stringent eligibility criteria exclude individuals with vulnerable characteristics, which we …

Senescence is the consequence of a signaling mechanism activated in stressed cells to
prevent proliferation of cells with damage. Senescent cells (Sncs) often develop a …