Curcumin, a yellow-colored molecule derived from the rhizome of Curcuma longa, has been
identified as the bioactive compound responsible for numerous pharmacological activities of …

In 1907 Alois Alzheimer observed, as he quoted, development of “numerous fibers” and
“adipose saccules” in the brain of his diseased patient Auguste Deter. The …

Proteinopathy and excessive production of reactive oxygen species (ROS), which are the
principal features observed in the Alzheimer's disease (AD) brain, contribute to neuronal …

Background Although the mechanism of neuron loss in Alzheimer's disease (AD) is
enigmatic, it is associated with cerebral accumulation of Aβ 42. The 5XFAD mouse model of …

Considerable evidence suggests that mitochondrial dysfunction and oxidative stress
contribute to the progression of Alzheimer's disease (AD). We examined the ability of the …

Although amyloid‐β peptide (Aβ) is the neurotoxic species implicated in the pathogenesis of
Alzheimer's disease (AD), mechanisms through which intracellular Aβ impairs cellular …

β-Amyloid (βA) peptide is strongly implicated in the neurodegeneration underlying
Alzheimer's disease, but the mechanisms of neurotoxicity remain controversial. This study …

Despite our present knowledge of some of the cellular pathways that modulate central
nervous system injury, complete therapeutic prevention or reversal of acute or chronic …

The aging process is accompanied by the onset of disease and a general decline in
wellness. Insights into the aging process have revealed a number of cellular hallmarks of …

Alzheimer's disease (AD) is a late‐onset dementia that is characterized by the loss of
memory and an impairment of multiple cognitive functions. Advancements in molecular …