Continued elucidation of the mechanisms of hepatic fibrosis has yielded a comprehensive
and nuanced portrait of fibrosis progression and regression. The paradigm of hepatic …

Herbal drugs, which possess immunomodulatory, anti-inflammatory, anti-diabetic, anti-
infective, and anti-allergic activities, encompass various therapeutic areas, and have been …

Lipid nanoparticle-mediated RNA delivery holds great potential to treat various liver
diseases. However, targeted delivery of RNA therapeutics to activated liver-resident …

Ferroptosis is a form of regulated cell death, characterized by excessive membrane lipid
peroxidation in an iron-and ROS-dependent manner. Celastrol, a natural bioactive …

Background & Aims Interactions between CC chemokine receptor types 2 (CCR2) and 5
(CCR5) and their ligands, including CCL2 and CCL5, mediate fibrogenesis by promoting …

Given that little is known about the prevalence of, and factors associated with, liver fibrosis in
the general population, we aimed to investigate this in a large, well‐characterized cohort by …

Sarcopenia is associated with nonalcoholic fatty liver disease (NAFLD). This study
investigated whether sarcopenia is associated with significant liver fibrosis in subjects with …

The clinical and public health significance of nonalcoholic fatty liver disease (NAFLD) is not
well established. We investigated the long-term effect of NAFLD on mortality. This analysis …

Liver disease is one of the leading causes of death worldwide. Patients with cirrhosis display
an increased predisposition to and mortality from infection due to multimodal defects in the …

Liver fibrosis is a very common condition seen in millions of patients with various liver
diseases, and yet no effective treatments are available owing to poorly characterized …