Advanced glycation end-products (AGEs): Formation, chemistry, classification, receptors, and diseases related to AGEs

A Twarda-Clapa, A Olczak, AM Białkowska… - Cells, 2022 - mdpi.com
Advanced glycation end-products (AGEs) constitute a non-homogenous, chemically diverse
group of compounds formed either exogeneously or endogeneously on the course of …

Pathophysiology of RAGE in inflammatory diseases

H Dong, Y Zhang, Y Huang, H Deng - Frontiers in Immunology, 2022 - frontiersin.org
The receptor for advanced glycation end products (RAGE) is a non-specific multi-ligand
pattern recognition receptor capable of binding to a range of structurally diverse ligands …

[HTML][HTML] Quercetin facilitates cell death and chemosensitivity through RAGE/PI3K/AKT/mTOR axis in human pancreatic cancer cells

CY Lan, SY Chen, CW Kuo, CC Lu, GC Yen - Journal of food and drug …, 2019 - Elsevier
The triggering of gemcitabine (GEM) drug resistance in pancreatic cancer by the receptor for
advanced glycation end products (RAGE) has been demonstrated. Hence, finding a safe …

The receptor for advanced glycation end-products (RAGE) is an important pattern recognition receptor (PRR) for inflammaging

T Teissier, É Boulanger - Biogerontology, 2019 - Springer
The receptor for advanced glycation end-products (RAGE) was initially characterized and
named for its ability to bind to advanced glycation end-products (AGEs) that form upon the …

Mechanisms of obesity-and diabetes mellitus-related pancreatic carcinogenesis: a comprehensive and systematic review

R Ruze, J Song, X Yin, Y Chen, R Xu… - Signal transduction and …, 2023 - nature.com
Research on obesity-and diabetes mellitus (DM)-related carcinogenesis has expanded
exponentially since these two diseases were recognized as important risk factors for …

Immunotherapy in small cell lung cancer

G Esposito, G Palumbo, G Carillio, A Manzo… - Cancers, 2020 - mdpi.com
Simple Summary Small cell lung cancer (SCLC) accounts for about 15% of lung cancers
and it has limited therapeutic options and poor prognosis. There has been no real progress …

Atherosclerosis, diabetes mellitus, and cancer: common epidemiology, shared mechanisms, and future management

V Katsi, I Papakonstantinou, K Tsioufis - International Journal of …, 2023 - mdpi.com
The involvement of cardiovascular disease in cancer onset and development represents a
contemporary interest in basic science. It has been recognized, from the most recent …

Ursolic acid promotes apoptosis, autophagy, and chemosensitivity in gemcitabine‐resistant human pancreatic cancer cells

JH Lin, SY Chen, CC Lu, JA Lin… - Phytotherapy …, 2020 - Wiley Online Library
Gemcitabine (GEM) resistance in pancreatic adenocarcinoma mediated by the receptor for
advanced glycation end products (RAGE) has been demonstrated. Therefore, investigating …

Effect of non-enzymatic glycosylation in the epigenetics of cancer

S Rehman, M Aatif, Z Rafi, MY Khan, U Shahab… - Seminars in Cancer …, 2022 - Elsevier
The non-enzymatic glycosylation or non-enzymatic covalent modifications (NECMs) or
glycation of cellular proteins result in the generation and accumulation of advanced …

Autophagy: a key player in pancreatic cancer progression and a potential drug target

J Gillson, YS Abd El-Aziz, LYW Leck, PJ Jansson… - Cancers, 2022 - mdpi.com
Simple Summary With the mortality rate of pancreatic cancer predicted to rise over the
coming years, it is essential that effective treatment strategies are developed as soon as …