Stress-induced reinstatement of drug seeking: 20 years of progress
In human addicts, drug relapse and craving are often provoked by stress. Since 1995, this
clinical scenario has been studied using a rat model of stress-induced reinstatement of drug …
clinical scenario has been studied using a rat model of stress-induced reinstatement of drug …
Multiple roles for orexin/hypocretin in addiction
Orexins/hypocretins are hypothalamic peptides involved in arousal and wakefulness, but
also play a critical role in drug addiction and reward-related behaviors. Here, we review the …
also play a critical role in drug addiction and reward-related behaviors. Here, we review the …
Hindbrain noradrenergic A2 neurons: diverse roles in autonomic, endocrine, cognitive, and behavioral functions
L Rinaman - American Journal of Physiology-Regulatory …, 2011 - journals.physiology.org
Central noradrenergic (NA) signaling is broadly implicated in behavioral and physiological
processes related to attention, arousal, motivation, learning and memory, and homeostasis …
processes related to attention, arousal, motivation, learning and memory, and homeostasis …
Translational and reverse translational research on the role of stress in drug craving and relapse
Rationale and background High relapse rates during abstinence are a pervasive problem in
drug addiction treatment. Relapse is often associated with stress exposure, which can …
drug addiction treatment. Relapse is often associated with stress exposure, which can …
A corticotropin releasing factor pathway for ethanol regulation of the ventral tegmental area in the bed nucleus of the stria terminalis
Y Silberman, RT Matthews… - Journal of Neuroscience, 2013 - Soc Neuroscience
A growing literature suggests that catecholamines and corticotropin-releasing factor (CRF)
interact in a serial manner to activate the bed nucleus of the stria terminalis (BNST) to drive …
interact in a serial manner to activate the bed nucleus of the stria terminalis (BNST) to drive …
The intersection of stress and reward: BNST modulation of aversive and appetitive states
The bed nucleus of the stria terminalis (BNST) is widely acknowledged as a brain structure
that regulates stress and anxiety states, as well as aversive and appetitive behaviours. The …
that regulates stress and anxiety states, as well as aversive and appetitive behaviours. The …
[HTML][HTML] Neurobiological mechanisms of addiction: focus on corticotropin-releasing factor
GF Koob, EP Zorrilla - Current opinion in investigational drugs …, 2010 - ncbi.nlm.nih.gov
Drug addiction is a chronically relapsing disorder that is characterized by a compulsion to
take drugs and loss of control in limiting intake. Medications that are on the market for the …
take drugs and loss of control in limiting intake. Medications that are on the market for the …
Enhancement of cue-induced reinstatement of cocaine-seeking in rats by yohimbine: sex differences and the role of the estrous cycle
MW Feltenstein, AR Henderson, RE See - Psychopharmacology, 2011 - Springer
Rationale Previous studies have shown that female rats exhibit enhanced cocaine-seeking
across several phases of the addiction cycle when compared to males. Drug-seeking in …
across several phases of the addiction cycle when compared to males. Drug-seeking in …
Sex differences in guanfacine effects on drug craving and stress arousal in cocaine-dependent individuals
Currently, no FDA-approved medication exists for the treatment of cocaine use disorder.
Furthermore, as women become increasingly more at risk for the consequences of cocaine …
Furthermore, as women become increasingly more at risk for the consequences of cocaine …
Modeling cocaine relapse in rodents: Behavioral considerations and circuit mechanisms
Addiction is a chronic relapsing disorder, in that most addicted individuals who choose to
quit taking drugs fail to maintain abstinence in the long-term. Relapse is especially likely …
quit taking drugs fail to maintain abstinence in the long-term. Relapse is especially likely …