[HTML][HTML] limma powers differential expression analyses for RNA-sequencing and microarray studies
Abstract limma is an R/Bioconductor software package that provides an integrated solution
for analysing data from gene expression experiments. It contains rich features for handling …
for analysing data from gene expression experiments. It contains rich features for handling …
Advanced applications of RNA sequencing and challenges
Next-generation sequencing technologies have revolutionarily advanced sequence-based
research with the advantages of high-throughput, high-sensitivity, and high-speed. RNA-seq …
research with the advantages of high-throughput, high-sensitivity, and high-speed. RNA-seq …
Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer's disease
Background Disease-associated-microglia (DAM) represent transcriptionally-distinct and
neurodegeneration-specific microglial profiles with unclear significance in Alzheimer's …
neurodegeneration-specific microglial profiles with unclear significance in Alzheimer's …
Senescence is a developmental mechanism that contributes to embryonic growth and patterning
M Storer, A Mas, A Robert-Moreno, M Pecoraro… - Cell, 2013 - cell.com
Senescence is a form of cell-cycle arrest linked to tumor suppression and aging. However, it
remains controversial and has not been documented in nonpathologic states. Here we …
remains controversial and has not been documented in nonpathologic states. Here we …
Epigenome-wide association of DNA methylation markers in peripheral blood from Indian Asians and Europeans with incident type 2 diabetes: a nested case-control …
JC Chambers, M Loh, B Lehne, A Drong… - The lancet Diabetes & …, 2015 - thelancet.com
Summary Background Indian Asians, who make up a quarter of the world's population, are
at high risk of developing type 2 diabetes. We investigated whether DNA methylation is …
at high risk of developing type 2 diabetes. We investigated whether DNA methylation is …
Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance
Artemisinin resistance in Plasmodium falciparum threatens global efforts to control and
eliminate malaria. Polymorphisms in the kelch domain–carrying protein K13 are associated …
eliminate malaria. Polymorphisms in the kelch domain–carrying protein K13 are associated …
Digit patterning is controlled by a Bmp-Sox9-Wnt Turing network modulated by morphogen gradients
During limb development, digits emerge from the undifferentiated mesenchymal tissue that
constitutes the limb bud. It has been proposed that this process is controlled by a self …
constitutes the limb bud. It has been proposed that this process is controlled by a self …
The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression
The human genome contains many thousands of long noncoding RNAs (lncRNAs). While
several studies have demonstrated compelling biological and disease roles for individual …
several studies have demonstrated compelling biological and disease roles for individual …
Low-level processing of Illumina Infinium DNA methylation beadarrays
TJ Triche Jr, DJ Weisenberger… - Nucleic acids …, 2013 - academic.oup.com
We propose a novel approach to background correction for Infinium HumanMethylation data
to account for technical variation in background fluorescence signal. Our approach …
to account for technical variation in background fluorescence signal. Our approach …
Genome-wide analysis of long noncoding RNA stability
Transcriptomic analyses have identified tens of thousands of intergenic, intronic, and cis-
antisense long noncoding RNAs (lncRNAs) that are expressed from mammalian genomes …
antisense long noncoding RNAs (lncRNAs) that are expressed from mammalian genomes …