During fertilization, the egg and the sperm are supposed to contribute precisely one copy of
each chromosome to the embryo. However, human eggs frequently contain an incorrect …

It is well established that maternal age is associated with a rapid decline in the production of
healthy and high-quality oocytes resulting in reduced fertility in women older than 35 years …

Ovarian aging in women correlates with the progressive loss of both the number and quality
of oocytes. When these processes occur early or are accelerated, their clinical correlates are …

Reproductive capacity in women starts to decline beyond their mid-30s and pregnancies in
older women result in higher rates of miscarriage with aneuploidy. Age-related decline in …

Ovarian aging is a natural and physiological aging process characterized by loss of quantity
and quality of oocyte or follicular pool. As it is generally accepted that women are born with a …

ABSTRACT BACKGROUND The unbalanced transmission of chromosomes in human
gametes and early preimplantation embryos causes aneuploidy, which is a major cause of …

STUDY QUESTION Do mitochondria-targeted therapies reverse ageing-and oxidative stress-
induced spindle defects in oocytes from mice and humans? SUMMARY ANSWER Exposure …

Recent years have seen an increased interest in the role of oxidative stress (OS) in
pregnancy. Pregnancy inherently heightens susceptibility to OS, a condition fueled by a …

BACKGROUND Oocyte aging has significant clinical consequences, and yet no treatment
exists to address the age-related decline in oocyte quality. The lack of progress in the …

BACKGROUND Within the ovary, oocytes are stored in long-lived structures called
primordial follicles, each comprising a meiotically arrested oocyte, surrounded by somatic …