The RAF/MEK/ERK signaling pathway regulates diverse cellular processes as exemplified
by cell proliferation, differentiation, motility, and survival. Activation of ERK1/2 generally …

Numerous natural products originated from Chinese herbal medicine exhibit anti-cancer
activities, including anti-proliferative, pro-apoptotic, anti-metastatic, anti-angiogenic effects …

Triptolide and celastrol are predominantly active natural products isolated from the
medicinal plant Tripterygium wilfordii Hook F. These compounds exhibit similar …

Background: Recent epidemiologic studies have focused on the potential beneficial effects
of regional anesthetics, and the differences in cancer prognosis may be the result of …

Lung cancer is the leading cause of cancer‐related mortality both in men and women and
accounts for 18.4% of all cancer‐related deaths. Although advanced therapy methods have …

Purpose Non-small cell lung cancer (NSCLC) accounts for the majority of lung cancer. Lipid–
polymer hybrid nanoparticles (LPNs) combine the advantages of both polymeric …

As a natural product with various biological activities, triptolide (TP) has been reported in
anti-inflammatory, anti-tumor and anti-autoimmune studies. However, the narrow therapeutic …

The RNA-binding protein human antigen R (HuR) is a well-established regulator of gene
expression at the posttranscriptional level. Its dysregulation has been implicated in various …

The development of chemo-sensitizers is urgently needed to overcome 5-fluorouracil (5-FU)
therapeutic resistance and adverse toxicity in colorectal cancer. This work aims to evaluate …

Background/Aims: Melatonin, synthesized by the pineal gland and released into the blood,
appears to have antitumour properties; however, the mechanisms of its anti-cancer effects …