[HTML][HTML] Insights from 20 years of bacterial genome sequencing
Since the first two complete bacterial genome sequences were published in 1995, the
science of bacteria has dramatically changed. Using third-generation DNA sequencing, it is …
science of bacteria has dramatically changed. Using third-generation DNA sequencing, it is …
Systems strategies for developing industrial microbial strains
Industrial strain development requires system-wide engineering and optimization of cellular
metabolism while considering industrially relevant fermentation and recovery processes. It …
metabolism while considering industrially relevant fermentation and recovery processes. It …
Microbial interactions: from networks to models
Metagenomics and 16S pyrosequencing have enabled the study of ecosystem structure and
dynamics to great depth and accuracy. Co-occurrence and correlation patterns found in …
dynamics to great depth and accuracy. Co-occurrence and correlation patterns found in …
How antibiotics kill bacteria: from targets to networks
MA Kohanski, DJ Dwyer, JJ Collins - Nature Reviews Microbiology, 2010 - nature.com
Antibiotic drug–target interactions, and their respective direct effects, are generally well
characterized. By contrast, the bacterial responses to antibiotic drug treatments that …
characterized. By contrast, the bacterial responses to antibiotic drug treatments that …
Data based identification and prediction of nonlinear and complex dynamical systems
The problem of reconstructing nonlinear and complex dynamical systems from measured
data or time series is central to many scientific disciplines including physical, biological …
data or time series is central to many scientific disciplines including physical, biological …
A personal view on systems medicine and the emergence of proactive P4 medicine: predictive, preventive, personalized and participatory
L Hood, M Flores - New biotechnology, 2012 - Elsevier
Systems biology and the digital revolution are together transforming healthcare to a
proactive P4 medicine that is predictive, preventive, personalized and participatory. Systems …
proactive P4 medicine that is predictive, preventive, personalized and participatory. Systems …
[HTML][HTML] A validated regulatory network for Th17 cell specification
Th17 cells have critical roles in mucosal defense and are major contributors to inflammatory
disease. Their differentiation requires the nuclear hormone receptor RORγt working with …
disease. Their differentiation requires the nuclear hormone receptor RORγt working with …
Revealing strengths and weaknesses of methods for gene network inference
Numerous methods have been developed for inferring gene regulatory networks from
expression data, however, both their absolute and comparative performance remain poorly …
expression data, however, both their absolute and comparative performance remain poorly …
Tuning gene expression to changing environments: from rapid responses to evolutionary adaptation
Organisms are constantly exposed to a wide range of environmental changes, including
both short-term changes during their lifetime and longer-term changes across generations …
both short-term changes during their lifetime and longer-term changes across generations …
Reconstruction of biochemical networks in microorganisms
Abstract Systems analysis of metabolic and growth functions in microbial organisms is
rapidly developing and maturing. Such studies are enabled by reconstruction, at the …
rapidly developing and maturing. Such studies are enabled by reconstruction, at the …