Intracellular delivery is a key step in biological research and has enabled decades of
biomedical discoveries. It is also becoming increasingly important in industrial and medical …

Objective Mitochondria are multifunctional life-sustaining organelles that represent a
potential intersection point between psychosocial experiences and biological stress …

Caloric restriction that promotes weight loss is an effective strategy for treating non-alcoholic
fatty liver disease and improving insulin sensitivity in people with type 2 diabetes. Despite its …

NAD+ availability decreases with age and in certain disease conditions. Nicotinamide
mononucleotide (NMN), a key NAD+ intermediate, has been shown to enhance NAD+ …

Nicotinamide adenine dinucleotide (NAD) levels decrease during aging and are involved in
age-related metabolic decline. To date, the mechanism responsible for the age-related …

A decline in capillary density and blood flow with age is a major cause of mortality and
morbidity. Understanding why this occurs is key to future gains in human health. NAD …

Rationale: Heart failure with preserved ejection fraction (HFpEF) is a mortal clinical
syndrome without effective therapies. We recently demonstrated in mice that a combination …

Background: Myocardial metabolic impairment is a major feature in chronic heart failure. As
the major coenzyme in fuel oxidation and oxidative phosphorylation and a substrate for …

Mitochondrial DNA (mtDNA) is a highly potent inflammatory trigger and is reportedly found
outside the cells in blood in various pathologies. Platelets are abundant in blood where they …

Mitochondria form a complex, interconnected reticulum that is maintained through
coordination among biogenesis, dynamic fission, and fusion and mitophagy, which are …