Ethnobotany and the role of plant natural products in antibiotic drug discovery
The crisis of antibiotic resistance necessitates creative and innovative approaches, from
chemical identification and analysis to the assessment of bioactivity. Plant natural products …
chemical identification and analysis to the assessment of bioactivity. Plant natural products …
Marine natural products
Covering: January to December 2017 This review covers the literature published in 2017 for
marine natural products (MNPs), with 740 citations (723 for the period January to December …
marine natural products (MNPs), with 740 citations (723 for the period January to December …
Reproducible molecular networking of untargeted mass spectrometry data using GNPS
Abstract Global Natural Product Social Molecular Networking (GNPS) is an interactive online
small molecule–focused tandem mass spectrometry (MS2) data curation and analysis …
small molecule–focused tandem mass spectrometry (MS2) data curation and analysis …
Bioactivity-based molecular networking for the discovery of drug leads in natural product bioassay-guided fractionation
LF Nothias, M Nothias-Esposito… - Journal of natural …, 2018 - ACS Publications
It is a common problem in natural product therapeutic lead discovery programs that despite
good bioassay results in the initial extract, the active compound (s) may not be isolated …
good bioassay results in the initial extract, the active compound (s) may not be isolated …
Accelerating metabolite identification in natural product research: toward an ideal combination of liquid chromatography–high-resolution tandem mass spectrometry …
Natural product research aims to characterize specialized metabolites from various living
organisms and assess their biological properties from either a chemical ecology or drug …
organisms and assess their biological properties from either a chemical ecology or drug …
Natural products targeting strategies involving molecular networking: different manners, one goal
Covering: up to 2019 Landmark advances in bioinformatics tools have recently enhanced
the field of natural products research, putting today's natural product chemists in the …
the field of natural products research, putting today's natural product chemists in the …
A convolutional neural network-based approach for the rapid annotation of molecularly diverse natural products
This report describes the first application of the novel NMR-based machine learning tool
“Small Molecule Accurate Recognition Technology”(SMART 2.0) for mixture analysis and …
“Small Molecule Accurate Recognition Technology”(SMART 2.0) for mixture analysis and …
Innovative omics-based approaches for prioritisation and targeted isolation of natural products–new strategies for drug discovery
Covering: 2013 to 2019 The exploration of the chemical diversity of extracts from various
biological sources has led to major drug discoveries. Over the past two decades, despite the …
biological sources has led to major drug discoveries. Over the past two decades, despite the …
Bioactive natural products prioritization using massive multi-informational molecular networks
Natural products represent an inexhaustible source of novel therapeutic agents. Their
complex and constrained three-dimensional structures endow these molecules with …
complex and constrained three-dimensional structures endow these molecules with …
Current status and contemporary approaches to the discovery of antitumor agents from higher plants
G Agarwal, PJB Carcache, EM Addo… - Biotechnology advances, 2020 - Elsevier
Higher plant constituents have afforded clinically available anticancer drugs. These include
both chemically unmodified small molecules and their synthetic derivatives currently used or …
both chemically unmodified small molecules and their synthetic derivatives currently used or …