Aluminum-containing adjuvants have been used for over 90 years to enhance the immune
response to vaccines. Recent work has significantly advanced our understanding of the …

Researchers working on the development of vaccines face an inherent dilemma: to
maximize immunogenicity without compromising safety and tolerability. Early vaccines often …

Adjuvants are central to the efficacy of subunit vaccines. Aluminum hydroxide (alum) is the
most commonly used vaccine adjuvant, yet its adjuvanticity is often weak and mechanisms …

In the past few decades, hundreds of materials have been tried as adjuvant; however, only
aluminum-based adjuvants continue to be used widely in the world. Aluminum hydroxide …

Aluminum (Al) is a ubiquitous substance encountered both naturally (as the third most
abundant element) and intentionally (used in water, foods, pharmaceuticals, and vaccines); …

Instability of vaccines often emerges as a key challenge during clinical development (lab to
clinic) as well as commercial distribution (factory to patient). To yield stable, efficacious …

Aluminum-containing adjuvants are widely used in preventive vaccines against infectious
diseases and in preparations for allergy immunotherapy. The mechanism by which they …

Alum adjuvants have been in continuous clinical use for more than 80 yr. While the
prevailing theory has been that depot formation and the associated slow release of antigen …

Aluminum hydroxide is used as a vaccine adjuvant in various human vaccines.
Unfortunately, despite its favorable safety profile, aluminum hydroxide can only weakly or …

Aluminum-containing adjuvants are an important component of many vaccines because
they safely potentiate the immune response. The structure and properties of aluminum …