Exposure to stress is an undeniable, but in most cases surmountable, part of life. However,
in certain individuals, exposure to severe or cumulative stressors can lead to an array of …

The endocannabinoid (eCB) system has attracted attention for its role in various behavioral
and brain functions, and as a therapeutic target in neuropsychiatric disease states, including …

Preclinical and clinical studies implicate endocannabinoids (eCBs) in fear extinction, but the
underlying neural circuit basis of these actions is unclear. Here, we employed in vivo …

The endocannabinoid (eCB) system is one the most ubiquitous signaling systems of the
brain and offers a rich pharmacology including multiple druggable targets. Preclinical …

Deficits in social interaction (SI) are a core symptom of autism spectrum disorders (ASDs);
however, treatments for social deficits are notably lacking. Elucidating brain circuits and …

Abstract Purpose of Review Anxiety-and trauma-related disorders are prevalent and
debilitating mental illnesses associated with a significant socioeconomic burden. Current …

Monoacylglycerol lipase (MAGL) has been characterized as the main enzyme responsible
for the inactivation of the most abundant brain endocannabinoid, 2-arachidonoylglycerol (2 …

Monoglyerides (MGs) are short-lived, intermediary lipids deriving from the degradation of
phospho-and neutral lipids, and monoglyceride lipase (MGL), also designated as …

Background and Purpose Women are twice as likely as men to develop post‐traumatic
stress disorder (PTSD) making the search for biological mechanisms underlying these …

Acquisition and extinction of learned fear responses utilize conserved but flexible neural
circuits. Here we show that acquisition of conditioned freezing behavior is associated with …