Benzodiazepines are frequently prescribed on an ongoing basis to individuals with
depression, mainly to alleviate anxiety or insomnia, despite current guideline …

Striatal dopamine (DA) release is critical for motivated actions and reinforcement learning,
and is locally influenced at the level of DA axons by other striatal neurotransmitters. Here …

Increased use of benzodiazepines in adolescents have been reported, with alprazolam
(ALP) being the most abused. Drug abuse during adolescence can induce changes with …

Benzodiazepines make up a class of psychoactive drugs that act as allosteric co-activators
of the inhibitory GABAA receptor. These drugs are useful for the treatment of several …

Mesolimbic dopamine transmission is dysregulated in multiple psychiatric disorders,
including addiction. Previous studies found that the endogenous GABAergic steroid (3α, 5α) …

Many psychoactive compounds have been shown to primarily interact with high-affinity and
low-capacity solute carrier 6 (SLC6) monoamine transporters for norepinephrine (NET; …

Growing research indicates oxytocin may be involved in relieving anxiety and attenuating
the rewarding effects of psychostimulants. This study investigated the effects of subchronic …

Benzodiazepines are commonly prescribed anxiolytics that pose abuse liability in
susceptible individuals. Although it is well established that all drugs of abuse increase brain …

Background and Purpose Currently, there is no effective drug to treat cocaine‐use disorder,
which affects millions of people worldwide. Benzodiazepines are potential therapeutic …

Although the benzodiazepine class of drugs has proven useful in treating anxiety symptoms,
recent studies yield no consistent empirical support for their use in treating psychiatric …