Cancer stem cells (CSCs), a small subset of cells in tumors that are characterized by self-
renewal and continuous proliferation, lead to tumorigenesis, metastasis, and maintain tumor …

Cancer stem cells (CSCs), which have the potential for self-renewal, differentiation and de-
differentiation, undergo epigenetic, epithelial-mesenchymal, immunological and metabolic …

Intrahepatic cholangiocarcinoma (iCCA) has over the last 10‐20 years become the focus of
increasing concern, largely due to its rising incidence and high mortality rates worldwide …

Colorectal cancer is one of the most common cancers worldwide with high mortality. Distant
metastasis and relapse are major causes of patient death. Cancer stem cells (CSCs) play a …

Liver cancer is an often fatal malignant tumor with a high recurrence rate and
chemoresistance. The major malignant phenotypes of cancer, including recurrence …

Based on our recent finding that disruption of bile acid (BA) homeostasis in mice results in
the induction of hepatic long noncoding RNA H19 expression, we sought to elucidate the …

Cancer stemness, referring to the stem-cell-like phenotype of cancer cells, has been
recognised to play important roles in different aspects of hepatocarcinogenesis. A number of …

Insulin-like Growth Factor (IGF)/IGF-1 Receptor (IGF-1R) signaling is known to regulate stem
cell pluripotency and differentiation to trigger cell proliferation, organ development, and …

Chronic hepatitis B virus (HBV) infection is a major risk factor for hepatocellular carcinoma
(HCC) and current treatments for chronic hepatitis B and HCC are suboptimal. Herein, we …

Background Natural killer (NK) cells can recognize and kill cancer cells directly, but their
activity can be attenuated by various inhibitory molecules expressed on the surface. The …