A large number of chemicals and several physical agents, such as UV light and γ-radiation,
have been associated with the etiology of human cancer. Generation of DNA damage (also …

Background PCNA (proliferating cell nuclear antigen) has been found in the nuclei of yeast,
plant and animal cells that undergo cell division, suggesting a function in cell cycle …

CrAssphage is the most abundant human-associated virus and the founding member of a
large group of bacteriophages, discovered in animal-associated and environmental …

Life as we know it, simply would not exist without DNA replication. All living organisms utilize
a complex machinery to duplicate their genomes and the central role in this machinery …

DNA double-strand breaks (DSBs) are common lesions that continually threaten genomic
integrity. Failure to repair a DSB has deleterious consequences, including cell death …

Non-homologous DNA end-joining (NHEJ)—the main pathway for repairing double-
stranded DNA breaks—functions throughout the cell cycle to repair such lesions. Defects in …

The structure, function and reactions of nucleic acids are central to molecular biology and
are crucial for the understanding of complex biological processes involved. Revised and …

▪ Abstract This review focuses on eukaryotic translesion synthesis (TLS) DNA polymerases,
and the emphasis is on Saccharomyces cerevisiae and human Y-family polymerases (Pols) …

The eukaryotic replicative DNA polymerases (Pol α, δ and ɛ) and the major DNA
mutagenesis enzyme Pol ζ contain two conserved cysteine-rich metal-binding motifs (CysA …

Abstract Iron–sulfur (Fe–S) clusters are versatile protein cofactors that require numerous
components for their synthesis and insertion into apoproteins. In eukaryotes, maturation of …