G protein-gated inwardly rectifying potassium (GIRK) channels hyperpolarize neurons in
response to activation of many different G protein-coupled receptors and thus control the …

G protein βγ subunits are central participants in G protein-coupled receptor signaling
pathways. They interact with receptors, G protein α subunits and downstream targets to …

Inwardly rectifying K+ (Kir) channels have a wide range of functions including the control of
neuronal signalling, heart rate, blood flow and insulin release. Because of the physiological …

G-protein-coupled inwardly rectifying potassium channels (GIRKs) are important for
regulation of synaptic transmission and neuronal firing rates. Because of their key role in …

G-protein βγ subunits are key participants in G-protein signaling. These subunits facilitate
interactions between receptors and G proteins that are critical for the G protein activation …

Ion channels are end-targets (effectors) in a large number of regulatory pathways that are
initiated by G-protein-coupled neurotransmitters and hormones. Modulation of ion channels …

Ethanol modifies neural activity in the brain by modulating ion channels. Ethanol activates G
protein–gated inwardly rectifying K+ channels, but the molecular mechanism is not well …

G protein-gated inwardly rectifying K+ (GIRK/Kir3) channels exert a critical inhibitory
influence on neurons. Neuronal GIRK channels mediate the G protein-dependent …

Activation of K+ channels by the G protein βγ subunits is an important signaling mechanism
of G-protein-coupled receptors. Typically, receptor-activated K+ currents desensitize in the …

GIRK (Kir3) channels are activated by neurotransmitters coupled to G proteins, via a direct
binding of G βγ. The role of Gα subunits in GIRK gating is elusive. Here we demonstrate that …