From sewer to saviour—targeting the lymphatic system to promote drug exposure and activity
The lymphatic system serves an integral role in fluid homeostasis, lipid metabolism and
immune control. In cancer, the lymph nodes that drain solid tumours are a primary site of …
immune control. In cancer, the lymph nodes that drain solid tumours are a primary site of …
Nanoparticle-based immunotherapy for cancer
The design of nanovaccines capable of triggering effective antitumor immunity requires an
understanding of how the immune system senses and responds to threats, including …
understanding of how the immune system senses and responds to threats, including …
Engineering nano‐and microparticles to tune immunity
The immune system can be a cure or cause of disease, fulfilling a protective role in attacking
cancer or pathogenic microbes but also causing tissue destruction in autoimmune disorders …
cancer or pathogenic microbes but also causing tissue destruction in autoimmune disorders …
T‐cell receptor proximal signaling via the Src‐family kinases, Lck and Fyn, influences T‐cell activation, differentiation, and tolerance
RJ Salmond, A Filby, I Qureshi, S Caserta… - Immunological …, 2009 - Wiley Online Library
T‐cell development in the thymus and activation of mature T cells in secondary lymphoid
organs requires the ability of cells to respond appropriately to environmental signals at …
organs requires the ability of cells to respond appropriately to environmental signals at …
Biomaterials to enhance antigen-specific T cell expansion for cancer immunotherapy
T cells are often referred to as the 'guided missiles' of our immune system because of their
capacity to traffic to and accumulate at sites of infection or disease, destroy infected or …
capacity to traffic to and accumulate at sites of infection or disease, destroy infected or …
Leveraging biomaterials for enhancing T cell immunotherapy
The dynamic roles of T cells in the immune system to recognize and destroy the infected or
mutated cells render T cell therapy a prospective treatment for a variety of diseases …
mutated cells render T cell therapy a prospective treatment for a variety of diseases …
Nanoparticle-based modulation of the immune system
The immune system is an incredibly complex biological network that plays a significant role
in almost all disease pathogenesis. With an increased understanding of how this vital …
in almost all disease pathogenesis. With an increased understanding of how this vital …
Rapid expansion of highly functional antigen-specific T cells from patients with melanoma by nanoscale artificial antigen-presenting cells
J Ichikawa, T Yoshida, A Isser, AS Laino… - Clinical Cancer …, 2020 - AACR
Purpose: Generation of antigen-specific T cells from patients with cancer employs large
numbers of peripheral blood cells and/or tumor-infiltrating cells to generate antigen …
numbers of peripheral blood cells and/or tumor-infiltrating cells to generate antigen …
Combination of DC/CIK adoptive T cell immunotherapy with chemotherapy in advanced non-small-cell lung cancer (NSCLC) patients: a prospective patients' …
Y Zhao, G Qiao, X Wang, Y Song, X Zhou… - Clinical and …, 2019 - Springer
Background Advanced non-small cell lung cancer (NSCLC) has remained challenging to
treat effectively. This study aimed to investigate the clinical effects and safety of …
treat effectively. This study aimed to investigate the clinical effects and safety of …
[PDF][PDF] TCR+/BCR+ dual-expressing cells and their associated public BCR clonotype are not enriched in type 1 diabetes
Ahmed and colleagues recently described a novel hybrid lymphocyte expressing both a B
and T cell receptor, termed double expresser (DE) cells. DE cells in blood of type 1 diabetes …
and T cell receptor, termed double expresser (DE) cells. DE cells in blood of type 1 diabetes …