A guide to the organ-on-a-chip

CM Leung, P De Haan… - Nature Reviews …, 2022 - nature.com
Abstract Organs-on-chips (OoCs) are systems containing engineered or natural miniature
tissues grown inside microfluidic chips. To better mimic human physiology, the chips are …

Brain-on-a-chip: Recent advances in design and techniques for microfluidic models of the brain in health and disease

L Amirifar, A Shamloo, R Nasiri, NR de Barros… - Biomaterials, 2022 - Elsevier
Recent advances in biomaterials, microfabrication, microfluidics, and cell biology have led to
the development of organ-on-a-chip devices that can reproduce key functions of various …

Microfluidics for neuronal cell and circuit engineering

R Habibey, JE Rojo Arias, J Striebel… - Chemical …, 2022 - ACS Publications
The widespread adoption of microfluidic devices among the neuroscience and neurobiology
communities has enabled addressing a broad range of questions at the molecular, cellular …

A review on microfluidics manipulation of the extracellular chemical microenvironment and its emerging application to cell analysis

P Chen, S Li, Y Guo, X Zeng, BF Liu - Analytica Chimica Acta, 2020 - Elsevier
Spatiotemporal manipulation of extracellular chemical environments with simultaneous
monitoring of cellular responses plays an essential role in exploring fundamental biological …

Microfluidics as an emerging precision tool in developmental biology

KF Sonnen, CA Merten - Developmental cell, 2019 - cell.com
Microfluidics has become a precision tool in modern biology. It enables omics data to be
obtained from individual cells, as compared to averaged signals from cell populations, and it …

[HTML][HTML] Engineered neural circuits for modeling brain physiology and neuropathology

S Bang, KS Hwang, S Jeong, IJ Cho, N Choi, J Kim… - Acta Biomaterialia, 2021 - Elsevier
The neural circuits of the central nervous system are the regulatory pathways for feeling,
motion control, learning, and memory, and their dysfunction is closely related to various …

Functional bioengineered models of the central nervous system

N Rouleau, NJ Murugan, DL Kaplan - Nature Reviews Bioengineering, 2023 - nature.com
The functional complexity of the central nervous system (CNS) is unparalleled in living
organisms. Its nested cells, circuits and networks encode memories, move bodies and …

Gradient conducting polymer surfaces with netrin-1-conjugation promote axon guidance and neuron transmission of human iPSC-derived retinal ganglion cells

JW She, CM Young, SJ Chou, YR Wu, YT Lin… - Biomaterials, 2025 - Elsevier
Major advances have been made in utilizing human-induced pluripotent stem cells (hiPSCs)
for regenerative medicine. Nevertheless, the delivery and integration of hiPSCs into target …

Multiscale brain research on a microfluidic chip

Y Zhao, U Demirci, Y Chen, P Chen - Lab on a Chip, 2020 - pubs.rsc.org
One major challenge in current brain research is generating an integrative understanding of
the brain's functions and disorders from its multiscale neuronal architectures and …

A radial microfluidic platform for higher throughput chemotaxis studies with individual gradient control

J Wu, A Kumar-Kanojia, S Hombach-Klonisch… - Lab on a Chip, 2018 - pubs.rsc.org
Chemotaxis plays a fundamental role in immune defense and cancer metastasis.
Microfluidic devices are increasingly applied to studying chemotaxis, owing to their …