Over the past two decades, bile acids (BAs) have become established as important
signaling molecules that enable fine-tuned inter-tissue communication from the liver, their …

Bilirubin has several physiological functions, both beneficial and harmful. In addition to
reactive oxygen species-scavenging activities, bilirubin has potent immunosuppressive …

Recent research on bilirubin, a historically well-known waste product of heme catabolism,
suggests an entirely new function as a metabolic hormone that drives gene transcription by …

Nuclear receptors are transcription factors which sense changing environmental or
hormonal signals and effect transcriptional changes to regulate core life functions including …

Bilirubin is a component of the heme catabolic pathway that is essential for liver function and
has been shown to reduce hepatic fat accumulation. High plasma bilirubin levels are …

Variability of drug metabolism, especially that of the most important phase I enzymes or
cytochrome P450 (CYP) enzymes, is an important complicating factor in many areas of …

Drug-metabolizing enzymes (DMEs) and transporters play pivotal roles in the disposition
and detoxification of numerous foreign and endogenous chemicals. To accommodate …

Bilirubin is a tetrapyrrolic compound originating from heme catabolism. Although originally
considered only a potentially dangerous waste product, it has become increasingly evident …

Cytochromes P450 are responsible for metabolism of most xenobiotics and are required for
the efficient elimination of foreign chemicals from the body. Paradoxically, these enzymes …

Bilirubin is an endogenous compound that can be toxic under certain conditions but, on the
other hand, mild unconjugated hyperbilirubinaemia might protect against cardiovascular …