Small‐molecule prodrug nanoassemblies: an emerging nanoplatform for anticancer drug delivery

G Li, B Sun, Y Li, C Luo, Z He, J Sun - Small, 2021 - Wiley Online Library
The antitumor efficiency and clinical translation of traditional nanomedicines is mainly
restricted by low drug loading, complex preparation technology, and potential toxicity …

Carrier-free nanomedicines for cancer treatment

LH Liu, XZ Zhang - Progress in Materials Science, 2022 - Elsevier
The last decade witnessed the great advances in the development of nanomedicines. As a
kind of attractive nanomedicine, carrier-free nanomedicines received extensive …

Self-assembling prodrugs

AG Cheetham, RW Chakroun, W Ma… - Chemical Society Reviews, 2017 - pubs.rsc.org
Covalent modification of therapeutic compounds is a clinically proven strategy to devise
prodrugs with enhanced treatment efficacies. This prodrug strategy relies on the modified …

Lipid–drug conjugate for enhancing drug delivery

D Irby, C Du, F Li - Molecular pharmaceutics, 2017 - ACS Publications
Lipid–drug conjugates (LDCs) are drug molecules that have been covalently modified with
lipids. The conjugation of lipids to drug molecules increases lipophilicity and also changes …

Nanoparticulation of prodrug into medicines for cancer therapy

Y Zhang, H Cui, R Zhang, H Zhang… - Advanced …, 2021 - Wiley Online Library
This article provides a broad spectrum about the nanoprodrug fabrication advances co‐
driven by prodrug and nanotechnology development to potentiate cancer treatment. The …

Carrier-free nanodrugs for safe and effective cancer treatment

S Karaosmanoglu, M Zhou, B Shi, X Zhang… - Journal of Controlled …, 2021 - Elsevier
Clinical applications of many anti-cancer drugs are restricted due to their hydrophobic
nature, requiring use of harmful organic solvents for administration, and poor selectivity and …

Prodrug-based nanoparticulate drug delivery strategies for cancer therapy

C Luo, J Sun, B Sun, Z He - Trends in pharmacological sciences, 2014 - cell.com
Despite the rapid developments in nanotechnology and biomaterials, the efficient delivery of
chemotherapeutic agents is still challenging. Prodrug-based nanoassemblies have many …

Vitamin E-based nanomedicines for anti-cancer drug delivery

N Duhem, F Danhier, V Préat - Journal of Controlled Release, 2014 - Elsevier
This review aims to highlight the development of novel vitamin E conjugates for the
vectorization of active pharmaceutical ingredients through nanotechnologies. The physico …

Novel delivery approaches for cancer therapeutics

AK Mitra, V Agrahari, A Mandal, K Cholkar… - Journal of controlled …, 2015 - Elsevier
Currently, a majority of cancer treatment strategies are based on the removal of tumor mass
mainly by surgery. Chemical and physical treatments such as chemo-and radiotherapies …

Designer lipids for drug delivery: from heads to tails

AG Kohli, PH Kierstead, VJ Venditto, CL Walsh… - Journal of controlled …, 2014 - Elsevier
For four decades, liposomes composed of both naturally occurring and synthetic lipids have
been investigated as delivery vehicles for low molecular weight and macromolecular drugs …