Acute myocardial infarction (MI) inflicts massive injury to the coronary microcirculation
leading to vascular disintegration and capillary rarefication in the infarct region. Tissue …

Abstract Hypoxia‑ischemia (H‑I) is frequently observed in perinatal asphyxia and other
diseases. It can lead to serious cardiac injury, cerebral damage, neurological disability and …

Among many proangiogenic growth factors, angiopoietin-1 (Ang1, or ANGPT1) is unique
because it can induce distinctive vascular remodeling through highly organized …

Cardiac fibrosis occurs naturally after myocardial infarction. While the initially formed fibrotic
tissue prevents the infarcted heart tissue from rupture, the progression of cardiac fibrosis …

In patients with diabetes mellitus, the ability of ischemic tissue to synchronize the molecular
and cellular events leading to restoration of tissue perfusion in response to the …

In patients with diabetes, the hyperglycemia-driven excess generation of reactive oxygen
species (ROS) induces oxidative stress (OS) in a variety of tissues. OS is closely associated …

Innate immune and inflammatory responses have been implicated in myocardial
ischemia/reperfusion (I/R) injury. However, the mechanisms by which innate immunity and …

The morbidity and mortality of diabetes mellitus are mostly attributed to cardiovascular
complications. Despite tremendous advancement in glycemic control, anti-diabetic …

Objective—MicroRNAs are involved in many critical functions, including angiogenesis.
Ultrasound-targeted microbubble destruction (UTMD) is a noninvasive technique for …

Acute myocardial infarction (MI) caused by ischemia and reperfusion (IR) is the most
common cause of cardiac dysfunction due to local cell death and a temporally regulated …