The MAPK cascades are central signaling pathways that regulate a wide variety of
stimulated cellular processes, including proliferation, differentiation, apoptosis and stress …

The Ras/Raf/extracellular signal‐regulated kinase (ERK) signaling pathway plays a crucial
role in almost all cell functions and therefore requires exquisite control of its spatiotemporal …

This contribution will address the effect of aging on skin functions, with a particular focus on
skin permeability, wound healing, angiogenesis, lipogenesis, sweat production, immune …

Cellular senescence is a stable cell cycle arrest that limits the proliferation of pre-cancerous
cells. Here we demonstrate that scaffold-attachment-factor A (SAFA) and the long noncoding …

Cellular senescence is the permanent arrest of cell cycle, physiologically related to aging
and aging-associated diseases. Senescence is also recognized as a mechanism for limiting …

The process of skin aging in humans is complex and is induced by multiple factors, including
genetic and various environmental ones. In particular, the superposition of environmental …

Life expectancy has drastically increased over the last few decades worldwide, with
important social and medical burdens and costs. To stay healthy longer and to avoid chronic …

To address the biological heterogeneity of lung cancer, we studied 199 lung
adenocarcinomas by integrating genome-wide data on copy number alterations and gene …

In an immune response, CD4+ T cells expand into effector T cells and then contract to
survive as long-lived memory cells. To identify age-associated defects in memory cell …

Signaling by the extracellular signal-regulated kinase (ERK) pathway controls many cellular
processes, including cell division, death, and differentiation. In this second installment of a …