SARS-CoV-2 spike S1 subunit induces neuroinflammatory, microglial and behavioral sickness responses: Evidence of PAMP-like properties
MG Frank, KH Nguyen, JB Ball, S Hopkins… - Brain, behavior, and …, 2022 - Elsevier
SARS-CoV-2 infection produces neuroinflammation as well as neurological, cognitive (ie,
brain fog), and neuropsychiatric symptoms (eg, depression, anxiety), which can persist for …
brain fog), and neuropsychiatric symptoms (eg, depression, anxiety), which can persist for …
Exploring the immunogenic properties of SARS-CoV-2 structural proteins: PAMP: TLR signaling in the mediation of the neuroinflammatory and neurologic sequelae of …
MG Frank, M Fleshner, SF Maier - Brain, Behavior, and Immunity, 2023 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) produces an array of
neurologic and neuropsychiatric symptoms in the acute and post-acute phase of infection …
neurologic and neuropsychiatric symptoms in the acute and post-acute phase of infection …
4D live imaging and computational modeling of a functional gut-on-a-chip evaluate how peristalsis facilitates enteric pathogen invasion
A Boquet-Pujadas, T Feaugas, A Petracchini… - Science …, 2022 - science.org
Physical forces are essential to biological function, but their impact at the tissue level is not
fully understood. The gut is under continuous mechanical stress because of peristalsis. To …
fully understood. The gut is under continuous mechanical stress because of peristalsis. To …
Probing mechanisms of binding and allostery in the SARS-CoV-2 spike omicron variant complexes with the host receptor: revealing functional roles of the binding …
G Verkhivker, S Agajanian, R Kassab… - International Journal of …, 2022 - mdpi.com
In this study, we performed all-atom MD simulations of RBD–ACE2 complexes for BA. 1, BA.
1.1, BA. 2, and BA. 3 Omicron subvariants, conducted a systematic mutational scanning of …
1.1, BA. 2, and BA. 3 Omicron subvariants, conducted a systematic mutational scanning of …
Effects of spike protein and toxin-like peptides found in COVID-19 patients on human 3D neuronal/glial model undergoing differentiation: Possible implications for …
F Pistollato, M Petrillo, LA Clerbaux, G Leoni… - Reproductive …, 2022 - Elsevier
The possible neurodevelopmental consequences of SARS-CoV-2 infection are presently
unknown. In utero exposure to SARS-CoV-2 has been hypothesized to affect the developing …
unknown. In utero exposure to SARS-CoV-2 has been hypothesized to affect the developing …
Inhibition of TAK1/TAB2 complex formation by costunolide attenuates obesity cardiomyopathy via the NF-κB signaling pathway
B Ye, X Chen, Y Chen, W Lin, D Xu, Z Fang… - Phytomedicine, 2023 - Elsevier
Background Chronic and persistent obesity can lead to various complications, including
obesity cardiomyopathy. Inhibition of the inflammatory response is an effective measure for …
obesity cardiomyopathy. Inhibition of the inflammatory response is an effective measure for …
A loosened gating mechanism of RIG-I leads to autoimmune disorders
Abstract DDX58 encodes RIG-I, a cytosolic RNA sensor that ensures immune surveillance of
nonself RNAs. Individuals with RIG-IE510V and RIG-IQ517H mutations have increased …
nonself RNAs. Individuals with RIG-IE510V and RIG-IQ517H mutations have increased …
Probing conformational landscapes of binding and allostery in the SARS-CoV-2 omicron variant complexes using microsecond atomistic simulations and perturbation …
G Verkhivker, M Alshahrani, G Gupta, S Xiao… - Physical Chemistry …, 2023 - pubs.rsc.org
In this study, we systematically examine the conformational dynamics, binding and allosteric
communications in the Omicron BA. 1, BA. 2, BA. 3 and BA. 4/BA. 5 spike protein complexes …
communications in the Omicron BA. 1, BA. 2, BA. 3 and BA. 4/BA. 5 spike protein complexes …
Biomembrane force probe (BFP): Design, advancements, and recent applications to live‐cell mechanobiology
Mechanical forces play a vital role in biological processes at molecular and cellular levels,
significantly impacting various diseases such as cancer, cardiovascular disease, and COVID …
significantly impacting various diseases such as cancer, cardiovascular disease, and COVID …
S373P mutation stabilizes the receptor-binding domain of the spike protein in omicron and promotes binding
A cluster of several newly occurring mutations on Omicron is found at the β-core region of
the spike protein's receptor-binding domain (RBD), where mutation rarely happened before …
the spike protein's receptor-binding domain (RBD), where mutation rarely happened before …