[HTML][HTML] Microenvironmental regulation in tumor progression: interactions between cancer-associated fibroblasts and immune cells

D Gao, L Fang, C Liu, M Yang, X Yu, L Wang… - Biomedicine & …, 2023 - Elsevier
The tumor microenvironment (TME), the" soil" on which tumor cells grow, has an important
role in regulating the proliferation and metastasis of tumor cells as well as their response to …

Contextual AI models for single-cell protein biology

MM Li, Y Huang, M Sumathipala, MQ Liang… - Nature …, 2024 - nature.com
Understanding protein function and developing molecular therapies require deciphering the
cell types in which proteins act as well as the interactions between proteins. However …

Pan-cancer spatially resolved single-cell analysis reveals the crosstalk between cancer-associated fibroblasts and tumor microenvironment

C Ma, C Yang, A Peng, T Sun, X Ji, J Mi, L Wei… - Molecular Cancer, 2023 - Springer
Cancer-associated fibroblasts (CAFs) are a heterogeneous cell population that plays a
crucial role in remodeling the tumor microenvironment (TME). Here, through the integrated …

Tumor microenvironment: A playground for cells from multiple diverse origins

D Bharadwaj, M Mandal - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2024 - Elsevier
Tumor microenvironment is formed by various cellular and non-cellular components which
interact with one another and form a complex network of interactions. Some of these cellular …

An integrated single-cell transcriptomic dataset for non-small cell lung cancer

KH Prazanowska, SB Lim - Scientific Data, 2023 - nature.com
As single-cell RNA sequencing (scRNA-seq) has emerged as a great tool for studying
cellular heterogeneity within the past decade, the number of available scRNA-seq datasets …

Cancer-associated fibroblasts drive CXCL13 production in activated T cells via TGF-beta

RA O'Connor, BR Martinez, L Koppensteiner… - Frontiers in …, 2023 - frontiersin.org
Introduction Tumour-reactive T cells producing the B-cell attractant chemokine CXCL13, in
solid tumours, promote development of tertiary lymphoid structures (TLS) and are associated …

Refining the optimal CAF cluster marker for predicting TME-dependent survival expectancy and treatment benefits in NSCLC patients

K Li, R Wang, GW Liu, ZY Peng, JC Wang, GD Xiao… - Scientific Reports, 2024 - nature.com
The tumor microenvironment (TME) plays a pivotal role in the onset, progression, and
treatment response of cancer. Among the various components of the TME, cancer …

Contextualizing protein representations using deep learning on protein networks and single-cell data

MM Li, Y Huang, M Sumathipala, MQ Liang… - bioRxiv, 2023 - biorxiv.org
Understanding protein function and developing molecular therapies require deciphering the
cell types in which proteins act as well as the interactions between proteins. However …

Machine Learning and Single-Cell Analysis Identify Molecular Features of IPF-Associated Fibroblast Subtypes and Their Implications on IPF Prognosis

J Hou, Y Yang, X Han - International Journal of Molecular Sciences, 2023 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is a devastating lung disease of unknown cause, and the
involvement of fibroblasts in its pathogenesis is well recognized. However, a comprehensive …

TIMP1 is an early biomarker for detection and prognosis of lung cancer

E Dantas, A Murthy, T Ahmed, M Ahmed… - Clinical and …, 2023 - Wiley Online Library
Background Lung cancer remains the major cause of cancer‐related deaths worldwide.
Early stages of lung cancer are characterized by long asymptomatic periods that are …