Herein, we provide an account of the activation strain model of chemical reactivity and its
recent applications. In this model, the potential energy surface ΔE (ζ) along the reaction …

The distortion/interaction model has been used to explain and predict reactivity in a variety
of reactions where more common explanations, such as steric and electronic factors, do not …

We describe diverse approaches to various dienes and their utilization in the Diels–Alder
reaction to produce a variety of polycycles. The dienes covered here are prepared by simple …

Abstract Enantioselective organocatalytic asymmetric Diels-Alder reactions provide a facile
and efficient route to optically active functionalized cyclohexenes, which can be further …

The ligand-dependent selectivities in Ullmann-type reactions of amino alcohols with
iodobenzene by β-diketone-and 1, 10-phenanthroline-ligated CuI complexes were recently …

Despite the blossoming of reports of diastereodivergent synthesis over the past years,
switchable control of the stereochemistry of the bridgehead atoms of the fused frameworks …

We report an experimental and computational study of 3-silylarynes. The addition of
nucleophiles yield ortho-substituted products as a result of aryne distortion, but meta …

Catalytic carbonyl-olefin metathesis reactions have recently been developed as a powerful
tool for carbon–carbon bond formation. However, currently available synthetic protocols rely …

The power of the Diels–Alder reaction was expanded recently through the discovery by Li
and Danishefsky that cyclobutenone is an unusually reactive dienophile; importantly, the …

Synthesis of a potent inhibitor of bacterial protein synthesis, pleuromutilin, is described.
Assembly of the critical cyclooctane fragment relies on an oxidative ring-expansion, and …