Hox genes play key roles in axial patterning and regulating the regional identity of cells and
tissues in a wide variety of animals from invertebrates to vertebrates. Nested domains of Hox …

HOTTIP lncRNA is highly expressed in acute myeloid leukemia (AML) driven by MLL
rearrangements or NPM1 mutations to mediate HOXA topologically associated domain …

DNA is compacted into higher order structures that have major implications in gene
regulation. These structures allow for long-range interactions of DNA elements, such as the …

Three-dimensional (3D) genomics is the frontier field in the post-genomics era, its foremost
content is the relationship between chromatin spatial conformation and regulation of gene …

Expression quantitative trait locus detection has become increasingly important for
understanding how noncoding variants contribute to disease susceptibility and complex …

Recent technological advancements and genome-wide studies provide compelling
evidence that dynamic chromatin interaction and three-dimensional genome organization in …

Proper lymphopoiesis and immune responses depend on the spatiotemporal control of
multiple processes, including gene expression, DNA recombination and cell fate decisions …

Long non-coding RNA has emerged as a key regulator of myriad gene functions. One such
lncRNA mrhl, reported by our group, was found to have important role in spermatogenesis …

Cellular functions are regulated by signal transduction pathway networks consisting of
protein-modifying enzymes that control the activity of many downstream proteins. Protein …

Proper expression of Homeobox A cluster genes (HoxA) is essential for embryonic stem cell
(ESC) differentiation and individual development. However, mechanisms controlling precise …