Vascular tone of resistance arteries and arterioles determines peripheral vascular
resistance, contributing to the regulation of blood pressure and blood flow to, and within the …

Calcium sparks represent local, rapid, and transient calcium release events from a cluster of
ryanodine receptors (RyRs) in the sarcoplasmic reticulum. In arterial smooth muscle cells …

The roles played by ryanodine receptors (RyRs) and inositol 1, 4, 5-trisphosphate receptors
(IP3Rs) in vascular smooth muscle in the microcirculation remain unclear. Therefore, the …

Diabetes is a major risk factor for stroke. However, the molecular mechanisms involved in
cerebral artery dysfunction found in the diabetic patients are not completely elucidated. In …

Aims: The initiation of hypoxic pulmonary vasoconstriction (HPV) involves an increase in
cytosolic calcium ([Ca2+] i) in pulmonary artery (PA) smooth muscle cells (PASMCs). Both …

Sorcin is a penta-EF-hand protein that interacts with intracellular target proteins after Ca2+
binding. The sarcolemmal Na+/Ca2+ exchanger (NCX1) may be an important sorcin target …

Disruption of the dystrophin complex causes muscle injury, dysfunction, cell death and
fibrosis. Excess transforming growth factor (TGF) β signaling has been described in human …

In mesenteric arteries (MAs), aldosterone (ALDO) binds to the endogenous
mineralocorticoid receptor (MR) and increases the expression of the voltage-gated L-type …

Sorcin, a penta-EF hand Ca 2+-binding protein expressed in cardiomyocytes, is known to
interact with ryanodine receptors and other Ca 2+ regulatory proteins. To investigate sorcin's …

Ca+ sparklets are subcellular Ca2+ signals produced by the opening of sarcolemmal L-type
Ca2+ channels. Ca2+ sparklet activity varies within the sarcolemma of arterial myocytes. In …