Physicians should be aware of porphyrias, which could be responsible for unexplained
gastrointestinal, neurologic, or skin disorders. Despite their relative rarity and complexity …

A very recent epidemiological study provides preliminary evidence that living in habitats
located at 2500 m above sea level (masl) might protect from the development of severe …

Porphyrin and iron are ubiquitous and essential for sustaining life in virtually all living
organisms. Unlike iron, which exists in many forms, porphyrin macrocycles are mostly …

Acute hepatic porphyria (AHP) is a group of inherited metabolic disorders that affect hepatic
heme biosynthesis. They are associated with attacks of neurovisceral manifestations that …

During erythroid differentiation, the erythron must remodel its protein constituents so that the
mature red cell contains hemoglobin as the chief cytoplasmic protein component. For this,∼ …

PPTC7 is a resident mitochondrial phosphatase essential for maintaining proper
mitochondrial content and function. Newborn mice lacking Pptc7 exhibit aberrant …

Mitochondrion is the powerhouse of the cell. The research of nearly a century has expanded
our understanding of mitochondrion, far beyond the view that mitochondrion is an important …

During erythropoiesis, there is an enormous demand for the synthesis of the essential
cofactor of hemoglobin, heme. Heme is synthesized de novo via an eight enzyme-catalyzed …

Heme plays a critical role in catalyzing life-essential redox reactions in all cells, and its
synthesis must be tightly balanced with cellular requirements. Heme synthesis in eukaryotes …

Heme plays a central role in diverse, life-essential processes that range from ubiquitous,
housekeeping pathways such as respiration, to highly cell-specific ones such as oxygen …